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Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening.
Harupa A, De Las Heras L, Colmenarejo G, Lyons-Abbott S, Reers A, Caballero Hernandez I, Chung CW, Charter D, Myler PJ, Fernández-Menéndez RM, Calderón F, Palomo S, Rodríguez B, Berlanga M, Herreros-Avilés E, Staker BL, Fernández Álvaro E, Kaushansky A. Harupa A, et al. Among authors: kaushansky a. J Med Chem. 2020 Jan 23;63(2):591-600. doi: 10.1021/acs.jmedchem.9b01343. Epub 2020 Jan 8. J Med Chem. 2020. PMID: 31850752
Using machine learning to dissect host kinases required for Leishmania internalization and development.
Wei L, Barrie U, Aloisio GM, Khuong FTH, Arang N, Datta A, Kaushansky A, Wetzel DM. Wei L, et al. Among authors: kaushansky a. bioRxiv [Preprint]. 2024 Aug 4:2024.05.16.593986. doi: 10.1101/2024.05.16.593986. bioRxiv. 2024. Update in: Mol Biochem Parasitol. 2024 Dec;260:111651. doi: 10.1016/j.molbiopara.2024.111651 PMID: 38798624 Free PMC article. Updated. Preprint.
Host-targeted Interventions as an Exciting Opportunity to Combat Malaria.
Vijayan K, Wei L, Glennon EKK, Mattocks C, Bourgeois N, Staker B, Kaushansky A. Vijayan K, et al. Among authors: kaushansky a. Chem Rev. 2021 Sep 8;121(17):10452-10468. doi: 10.1021/acs.chemrev.1c00062. Epub 2021 Jul 1. Chem Rev. 2021. PMID: 34197083 Review.
Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.
Rodríguez-Hernández D, Vijayan K, Zigweid R, Fenwick MK, Sankaran B, Roobsoong W, Sattabongkot J, Glennon EKK, Myler PJ, Sunnerhagen P, Staker BL, Kaushansky A, Grøtli M. Rodríguez-Hernández D, et al. Among authors: kaushansky a. Nat Commun. 2023 Sep 5;14(1):5408. doi: 10.1038/s41467-023-41119-7. Nat Commun. 2023. PMID: 37669940 Free PMC article.
Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development.
Fenwick MK, Reers AR, Liu Y, Zigweid R, Sankaran B, Shin J, Hulverson MA, Hammerson B, Fernández Álvaro E, Myler PJ, Kaushansky A, Van Voorhis WC, Fan E, Staker BL. Fenwick MK, et al. Among authors: kaushansky a. ACS Infect Dis. 2023 Oct 13;9(10):1821-1833. doi: 10.1021/acsinfecdis.3c00151. Epub 2023 Sep 18. ACS Infect Dis. 2023. PMID: 37722671 Free PMC article.
89 results