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In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model.
McCallum FJ, Birrell GW, Chavchich M, Harris I, Obaldia N 3rd, Van Breda K, Heffernan GD, Jacobus DP, Shanks D, Edstein MD. McCallum FJ, et al. Among authors: heffernan gd. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01538-19. doi: 10.1128/AAC.01538-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31843994 Free PMC article.
JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Birrell GW, Chavchich M, Ager AL, Shieh HM, Heffernan GD, Zhao W, Krasucki PE, Saionz KW, Terpinski J, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Among authors: heffernan gd. Antimicrob Agents Chemother. 2015 Jan;59(1):170-7. doi: 10.1128/AAC.03762-14. Epub 2014 Oct 20. Antimicrob Agents Chemother. 2015. PMID: 25331702 Free PMC article.
Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Chavchich M, Birrell GW, Ager AL, MacKenzie DO, Heffernan GD, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Chavchich M, et al. Among authors: heffernan gd. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3115-8. doi: 10.1128/AAC.03066-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26856849 Free PMC article.
Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Birrell GW, Heffernan GD, Schiehser GA, Anderson J, Ager AL, Morales P, MacKenzie D, van Breda K, Chavchich M, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Among authors: heffernan gd. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01335-17. doi: 10.1128/AAC.01335-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29311093 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33451390
Relevance of Higher-Order Epistasis in Drug Resistance.
Lozovsky ER, Daniels RF, Heffernan GD, Jacobus DP, Hartl DL. Lozovsky ER, et al. Among authors: heffernan gd. Mol Biol Evol. 2021 Jan 4;38(1):142-151. doi: 10.1093/molbev/msaa196. Mol Biol Evol. 2021. PMID: 32745183 Free PMC article.
In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites.
Vydyam P, Chand M, Gihaz S, Renard I, Heffernan GD, Jacobus LR, Jacobus DP, Saionz KW, Shah R, Shieh H-M, Terpinski J, Zhao W, Cornillot E, Ben Mamoun C. Vydyam P, et al. Among authors: heffernan gd. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0042324. doi: 10.1128/aac.00423-24. Epub 2024 Aug 13. Antimicrob Agents Chemother. 2024. PMID: 39136469 Free PMC article.
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Heffernan GD, Coghlan RD, Manas ES, McDevitt RE, Li Y, Mahaney PE, Robichaud AJ, Huselton C, Alfinito P, Bray JA, Cosmi SA, Johnston GH, Kenney T, Koury E, Winneker RC, Deecher DC, Trybulski EJ. Heffernan GD, et al. Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. doi: 10.1016/j.bmc.2009.09.023. Epub 2009 Sep 18. Bioorg Med Chem. 2009. PMID: 19836247
11 results