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SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA. Greene KS, et al. Among authors: lin mj, lin h. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26625-26632. doi: 10.1073/pnas.1911954116. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2019. PMID: 31843902 Free PMC article.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H. Du J, et al. Among authors: lin h. Science. 2011 Nov 11;334(6057):806-9. doi: 10.1126/science.1207861. Science. 2011. PMID: 22076378 Free PMC article.
Metabolic characterization of a Sirt5 deficient mouse model.
Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Yu J, et al. Among authors: lin h. Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806. Sci Rep. 2013. PMID: 24076663 Free PMC article.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Abril YLN, et al. Among authors: lin h. Oncogene. 2021 Mar;40(9):1644-1658. doi: 10.1038/s41388-020-01637-w. Epub 2021 Jan 21. Oncogene. 2021. PMID: 33479498 Free PMC article.
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