Zhang X - Search Results

1

Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.

Li J, Ge Y, Huang JX, Strømgaard K, Zhang X, Xiong XF. Li J, et al. Among authors: zhang x. J Med Chem. 2020 May 28;63(10):5013-5030. doi: 10.1021/acs.jmedchem.9b01452. Epub 2019 Dec 26. J Med Chem. 2020. PMID: 31841625 Review.

2

Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?

Huang Q, Zhong Y, Dong H, Zheng Q, Shi S, Zhu K, Qu X, Hu W, Zhang X, Wang Y. Huang Q, et al. Among authors: zhang x. Eur J Med Chem. 2020 Feb 1;187:111922. doi: 10.1016/j.ejmech.2019.111922. Epub 2019 Nov 28. Eur J Med Chem. 2020. PMID: 31810784 Review.

3

Design, Synthesis, and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma.

Ge Y, Shi S, Deng JJ, Chen XP, Song Z, Liu L, Lou L, Zhang X, Xiong XF. Ge Y, et al. Among authors: zhang x. J Med Chem. 2021 Mar 25;64(6):3131-3152. doi: 10.1021/acs.jmedchem.0c01977. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715360

4

Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).

Huang Q, Zhong Y, Li B, Ouyang S, Deng L, Mo J, Shi S, Lv N, Wu R, Liu P, Hu W, Zhang X, Wang Y. Huang Q, et al. Among authors: zhang x. Eur J Med Chem. 2021 Oct 5;221:113525. doi: 10.1016/j.ejmech.2021.113525. Epub 2021 May 7. Eur J Med Chem. 2021. PMID: 34000483

5

Targeting mutated GTPase KRAS in tumor therapies.

Fan G, Lou L, Song Z, Zhang X, Xiong XF. Fan G, et al. Among authors: zhang x. Eur J Med Chem. 2021 Dec 15;226:113816. doi: 10.1016/j.ejmech.2021.113816. Epub 2021 Sep 4. Eur J Med Chem. 2021. PMID: 34520956 Review.

6

Discovery of Novel Benzo[4,5]imidazo[1,2-a]pyrazin-1-amine-3-amide-one Derivatives as Anticancer Human A_2A Adenosine Receptor Antagonists.

Liu S, Ding W, Huang W, Zhang Z, Guo Y, Zhang Q, Wu L, Li Y, Qin R, Li J, Shi T, Zhang X, Lei J, Hu W. Liu S, et al. Among authors: zhang q, zhang z, zhang x. J Med Chem. 2022 Jul 14;65(13):8933-8947. doi: 10.1021/acs.jmedchem.2c00101. Epub 2022 Jun 17. J Med Chem. 2022. PMID: 35714367

7

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.

Ge Y, Deng JJ, Zhu J, Liu L, Ouyang S, Song Z, Zhang X, Xiong XF. Ge Y, et al. Among authors: zhang x. Acta Pharm Sin B. 2022 Aug;12(8):3326-3340. doi: 10.1016/j.apsb.2022.04.016. Epub 2022 May 4. Acta Pharm Sin B. 2022. PMID: 35967274 Free PMC article.

8

Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.

Deng L, Mo J, Zhang Y, Peng K, Li H, Ouyang S, Feng Z, Fang W, Wei J, Rong D, Zhang X, Wang Y. Deng L, et al. Among authors: zhang x, zhang y. J Med Chem. 2022 Oct 13;65(19):13094-13111. doi: 10.1021/acs.jmedchem.2c00940. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170649

9

Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.

Li H, Ouyang S, Zhang Y, Peng K, Fang W, Liu Z, Wang CY, Zhang X, Wang Y. Li H, et al. Among authors: zhang x, zhang y. Eur J Med Chem. 2022 Dec 15;244:114858. doi: 10.1016/j.ejmech.2022.114858. Epub 2022 Oct 19. Eur J Med Chem. 2022. PMID: 36283181

10

Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.

Song Z, Lou L, Fan G, Liu L, Ge Y, Liu H, Chan ASC, Zhang X, Xiong XF. Song Z, et al. Among authors: zhang x. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114907. doi: 10.1016/j.ejmech.2022.114907. Epub 2022 Nov 9. Eur J Med Chem. 2023. PMID: 36395648

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