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KCa3.1 channel mediates inflammatory signaling of pancreatic β cells and progression of type 2 diabetes mellitus.
Pang ZD, Wang Y, Wang XJ, She G, Ma XZ, Song Z, Zhao LM, Wang HF, Lai BC, Gou W, Du XJ, Deng XL. Pang ZD, et al. Among authors: wang hf, wang xj, wang y. FASEB J. 2019 Dec;33(12):14760-14771. doi: 10.1096/fj.201901329RR. Epub 2019 Nov 5. FASEB J. 2019. PMID: 31690106
In summary, up-regulated K(Ca)3.1 due to activation of NF-kappaB pathway leads to pancreatic inflammation via expression and secretion of chemokines and cytokines by pancreatic beta cells, thereby facilitating progression of T2DM.-Pang, Z.-D., Wang, Y., Wang, …
In summary, up-regulated K(Ca)3.1 due to activation of NF-kappaB pathway leads to pancreatic inflammation via expression and secretion of ch …
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