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JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Birrell GW, Chavchich M, Ager AL, Shieh HM, Heffernan GD, Zhao W, Krasucki PE, Saionz KW, Terpinski J, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):170-7. doi: 10.1128/AAC.03762-14. Epub 2014 Oct 20. Antimicrob Agents Chemother. 2015. PMID: 25331702 Free PMC article.
Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Chavchich M, Birrell GW, Ager AL, MacKenzie DO, Heffernan GD, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Chavchich M, et al. Among authors: birrell gw. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3115-8. doi: 10.1128/AAC.03066-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26856849 Free PMC article.
Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Birrell GW, Heffernan GD, Schiehser GA, Anderson J, Ager AL, Morales P, MacKenzie D, van Breda K, Chavchich M, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01335-17. doi: 10.1128/AAC.01335-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29311093 Free PMC article.
In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model.
McCallum FJ, Birrell GW, Chavchich M, Harris I, Obaldia N 3rd, Van Breda K, Heffernan GD, Jacobus DP, Shanks D, Edstein MD. McCallum FJ, et al. Among authors: birrell gw. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01538-19. doi: 10.1128/AAC.01538-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31843994 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33451390
Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
Quang NN, Chavchich M, Anh CX, Birrell GW, van Breda K, Travers T, Rowcliffe K, Edstein MD. Quang NN, et al. Among authors: birrell gw. Am J Trop Med Hyg. 2018 Jul;99(1):65-72. doi: 10.4269/ajtmh.17-0434. Epub 2018 May 3. Am J Trop Med Hyg. 2018. PMID: 29741150 Free PMC article.
Pyronaridine-Artesunate (Pyramax) for Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam.
Manh ND, Thanh NV, Quang HH, Van NTT, San NN, Phong NC, Birrell GW, Edstein MD, Edgel KA, Martin NJ, Chavchich M. Manh ND, et al. Among authors: birrell gw. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0027621. doi: 10.1128/AAC.00276-21. Epub 2021 Sep 27. Antimicrob Agents Chemother. 2021. PMID: 34570647 Free PMC article. Clinical Trial.
68 results