Cross J - Search Results

1

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells.

Lemm EA, Valle-Argos B, Smith LD, Richter J, Gebreselassie Y, Carter MJ, Karolova J, Svaton M, Helman K, Weston-Bell NJ, Karydis L, Williamson CT, Lenz G, Pettigrew J, Harwig C, Stevenson FK, Cragg M, Forconi F, Steele AJ, Cross J, Mackenzie L, Klener P, Packham G. Lemm EA, et al. Among authors: cross j. Clin Cancer Res. 2020 Apr 1;26(7):1700-1711. doi: 10.1158/1078-0432.CCR-19-2202. Epub 2019 Dec 12. Clin Cancer Res. 2020. PMID: 31831562 Free PMC article.

2

AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis.

Cross J, Stenton GR, Harwig C, Szabo C, Genovese T, Di Paola R, Esposito E, Cuzzocrea S, Mackenzie LF. Cross J, et al. Br J Pharmacol. 2017 Sep;174(18):3045-3057. doi: 10.1111/bph.13934. Epub 2017 Aug 11. Br J Pharmacol. 2017. PMID: 28658529 Free PMC article.

3

Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo.

Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, MacRury T, Szabo C. Stenton GR, et al. Among authors: cross jl. Br J Pharmacol. 2013 Mar;168(6):1519-29. doi: 10.1111/bph.12038. Br J Pharmacol. 2013. PMID: 23121409 Free PMC article.

4

Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo.

Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T, Szabo C. Stenton GR, et al. Among authors: cross jl. Br J Pharmacol. 2013 Mar;168(6):1506-18. doi: 10.1111/bph.12039. Br J Pharmacol. 2013. PMID: 23121445 Free PMC article.

5

Tyrosine phosphorylation in immune cells: direct and indirect effects on toll-like receptor-induced proinflammatory cytokine production.

Johnson P, Cross JL. Johnson P, et al. Crit Rev Immunol. 2009;29(4):347-67. doi: 10.1615/critrevimmunol.v29.i4.50. Crit Rev Immunol. 2009. PMID: 19673688 Review.

6

CD45 regulates TLR-induced proinflammatory cytokine and IFN-beta secretion in dendritic cells.

Cross JL, Kott K, Miletic T, Johnson P. Cross JL, et al. J Immunol. 2008 Jun 15;180(12):8020-9. doi: 10.4049/jimmunol.180.12.8020. J Immunol. 2008. PMID: 18523265

7

CD44 interacts directly with Lck in a zinc-dependent manner.

Lefebvre DC, Lai JC, Maeshima N, Ford JL, Wong AS, Cross JL, Johnson P. Lefebvre DC, et al. Mol Immunol. 2010 Jun;47(10):1882-9. doi: 10.1016/j.molimm.2010.03.018. Epub 2010 Apr 24. Mol Immunol. 2010. PMID: 20417561

8

Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation.

Felberg J, Lefebvre DC, Lam M, Wang Y, Ng DH, Birkenhead D, Cross JL, Johnson P. Felberg J, et al. Among authors: cross jl. J Biol Chem. 2004 Jan 30;279(5):3455-62. doi: 10.1074/jbc.M309537200. Epub 2003 Nov 17. J Biol Chem. 2004. PMID: 14625311 Free article.

9

Hyaluronan binding identifies the most proliferative activated and memory T cells.

Maeshima N, Poon GF, Dosanjh M, Felberg J, Lee SS, Cross JL, Birkenhead D, Johnson P. Maeshima N, et al. Among authors: cross jl. Eur J Immunol. 2011 Apr;41(4):1108-19. doi: 10.1002/eji.201040870. Epub 2011 Mar 1. Eur J Immunol. 2011. PMID: 21360702 Free article.

10

Differential Effects of Voclosporin and Tacrolimus on Insulin Secretion From Human Islets.

Kolic J, Beet L, Overby P, Cen HH, Panzhinskiy E, Ure DR, Cross JL, Huizinga RB, Johnson JD. Kolic J, et al. Among authors: cross jl. Endocrinology. 2020 Nov 1;161(11):bqaa162. doi: 10.1210/endocr/bqaa162. Endocrinology. 2020. PMID: 32894758 Free PMC article.

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