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Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.
Dumas SJ, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha NV, Falkenberg K, Teuwen LA, de Rooij L, Kalucka J, Chen R, Khan S, Taverna F, Lu W, Parys M, De Legher C, Vinckier S, Karakach TK, Schoonjans L, Lin L, Bolund L, Dewerchin M, Eelen G, Rabelink TJ, Li X, Luo Y, Carmeliet P. Dumas SJ, et al. Among authors: li x. J Am Soc Nephrol. 2020 Jan;31(1):118-138. doi: 10.1681/ASN.2019080832. Epub 2019 Dec 9. J Am Soc Nephrol. 2020. PMID: 31818909 Free PMC article.
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P. Li X, et al. Among authors: li h. J Clin Invest. 2005 Jan;115(1):118-27. doi: 10.1172/JCI19189. J Clin Invest. 2005. PMID: 15630451 Free PMC article.
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. Li X, et al. Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1614-20. doi: 10.1161/ATVBAHA.107.158725. Epub 2008 May 29. Arterioscler Thromb Vasc Biol. 2008. PMID: 18511699 Free PMC article.
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.
Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, Ye Z, Huang L, Wang S, Ren X, Xing L, Chen W, Huang D, Gao Z, Zhang S, Lu W, Tang Z, Wang B, Ju R, Li X. Zheng L, et al. Among authors: li x. Oncotarget. 2016 Nov 22;7(47):77902-77915. doi: 10.18632/oncotarget.12843. Oncotarget. 2016. PMID: 27788490 Free PMC article.
Targeting angiogenic metabolism in disease.
Li X, Carmeliet P. Li X, et al. Science. 2018 Mar 23;359(6382):1335-1336. doi: 10.1126/science.aar5557. Science. 2018. PMID: 29567696 No abstract available.
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P. Vandekeere S, et al. Among authors: li x. Cell Metab. 2018 Oct 2;28(4):573-587.e13. doi: 10.1016/j.cmet.2018.06.009. Epub 2018 Jul 12. Cell Metab. 2018. PMID: 30017355 Free article.
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.
Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P. Bruning U, et al. Among authors: li x. Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23. Cell Metab. 2018. PMID: 30146486 Free PMC article.
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.
Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P, Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P. Kalucka J, et al. Among authors: li x. Cell Metab. 2018 Dec 4;28(6):881-894.e13. doi: 10.1016/j.cmet.2018.07.016. Epub 2018 Aug 23. Cell Metab. 2018. PMID: 30146488 Free article.
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