Hedger G - Search Results

1

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP. Wang Q, et al. Among authors: hedger g. Structure. 2020 Feb 4;28(2):169-184.e5. doi: 10.1016/j.str.2019.11.005. Epub 2019 Dec 2. Structure. 2020. PMID: 31806353 Free PMC article.

2

Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function.

Chavent M, Karia D, Kalli AC, Domański J, Duncan AL, Hedger G, Stansfeld PJ, Seiradake E, Jones EY, Sansom MSP. Chavent M, et al. Among authors: hedger g. Structure. 2018 Jul 3;26(7):1025-1034.e2. doi: 10.1016/j.str.2018.05.003. Epub 2018 Jun 7. Structure. 2018. PMID: 29887500 Free PMC article.

3

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP. Hedger G, et al. Structure. 2019 Mar 5;27(3):549-559.e2. doi: 10.1016/j.str.2018.11.003. Epub 2018 Dec 27. Structure. 2019. PMID: 30595453 Free PMC article.

4

The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids.

Hedger G, Sansom MS, Koldsø H. Hedger G, et al. Sci Rep. 2015 Mar 17;5:9198. doi: 10.1038/srep09198. Sci Rep. 2015. PMID: 25779975 Free PMC article.

5

Molecular simulations of glycolipids: Towards mammalian cell membrane models.

Shorthouse D, Hedger G, Koldsø H, Sansom MS. Shorthouse D, et al. Among authors: hedger g. Biochimie. 2016 Jan;120:105-9. doi: 10.1016/j.biochi.2015.09.033. Epub 2015 Sep 30. Biochimie. 2016. PMID: 26427555 Free PMC article. Review.

6

Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.

Hedger G, Sansom MSP. Hedger G, et al. Biochim Biophys Acta. 2016 Oct;1858(10):2390-2400. doi: 10.1016/j.bbamem.2016.02.037. Epub 2016 Mar 3. Biochim Biophys Acta. 2016. PMID: 26946244 Free PMC article. Review.

7

Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor.

Hedger G, Shorthouse D, Koldsø H, Sansom MS. Hedger G, et al. J Phys Chem B. 2016 Aug 25;120(33):8154-63. doi: 10.1021/acs.jpcb.6b01387. Epub 2016 May 9. J Phys Chem B. 2016. PMID: 27109430 Free PMC article.

8

Lipid-Loving ANTs: Molecular Simulations of Cardiolipin Interactions and the Organization of the Adenine Nucleotide Translocase in Model Mitochondrial Membranes.

Hedger G, Rouse SL, Domański J, Chavent M, Koldsø H, Sansom MS. Hedger G, et al. Biochemistry. 2016 Nov 15;55(45):6238-6249. doi: 10.1021/acs.biochem.6b00751. Epub 2016 Nov 4. Biochemistry. 2016. PMID: 27786441 Free PMC article.

9

Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association.

Domański J, Hedger G, Best RB, Stansfeld PJ, Sansom MSP. Domański J, et al. Among authors: hedger g. J Phys Chem B. 2017 Apr 20;121(15):3364-3375. doi: 10.1021/acs.jpcb.6b08445. Epub 2016 Nov 17. J Phys Chem B. 2017. PMID: 27807980 Free PMC article.

10

PtdIns(4,5)P₂ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling.

Yen HY, Hoi KK, Liko I, Hedger G, Horrell MR, Song W, Wu D, Heine P, Warne T, Lee Y, Carpenter B, Plückthun A, Tate CG, Sansom MSP, Robinson CV. Yen HY, et al. Among authors: hedger g. Nature. 2018 Jul;559(7714):423-427. doi: 10.1038/s41586-018-0325-6. Epub 2018 Jul 11. Nature. 2018. PMID: 29995853 Free PMC article.

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