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Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.
Fulco CP, Nasser J, Jones TR, Munson G, Bergman DT, Subramanian V, Grossman SR, Anyoha R, Doughty BR, Patwardhan TA, Nguyen TH, Kane M, Perez EM, Durand NC, Lareau CA, Stamenova EK, Aiden EL, Lander ES, Engreitz JM. Fulco CP, et al. Among authors: aiden el. Nat Genet. 2019 Dec;51(12):1664-1669. doi: 10.1038/s41588-019-0538-0. Epub 2019 Nov 29. Nat Genet. 2019. PMID: 31784727 Free PMC article.
Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism.
Pujadas EM, Wei X, Acosta N, Carter L, Yang J, Almassalha L, Daneshkhah A, Rao SSP, Agrawal V, Seker-Polat F, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas EM, et al. Among authors: aiden el. bioRxiv [Preprint]. 2023 Jun 26:2023.06.26.546573. doi: 10.1101/2023.06.26.546573. bioRxiv. 2023. Update in: Genome Biol. 2024 Mar 22;25(1):77. doi: 10.1186/s13059-024-03212-y PMID: 37425796 Free PMC article. Updated. Preprint.
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.
Sanborn AL, Rao SS, Huang SC, Durand NC, Huntley MH, Jewett AI, Bochkov ID, Chinnappan D, Cutkosky A, Li J, Geeting KP, Gnirke A, Melnikov A, McKenna D, Stamenova EK, Lander ES, Aiden EL. Sanborn AL, et al. Among authors: aiden el. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. doi: 10.1073/pnas.1518552112. Epub 2015 Oct 23. Proc Natl Acad Sci U S A. 2015. PMID: 26499245 Free PMC article.
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture.
Darrow EM, Huntley MH, Dudchenko O, Stamenova EK, Durand NC, Sun Z, Huang SC, Sanborn AL, Machol I, Shamim M, Seberg AP, Lander ES, Chadwick BP, Aiden EL. Darrow EM, et al. Among authors: aiden el. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4504-12. doi: 10.1073/pnas.1609643113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432957 Free PMC article.
Cohesin Loss Eliminates All Loop Domains.
Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, Huang X, Shamim MS, Shin J, Turner D, Ye Z, Omer AD, Robinson JT, Schlick T, Bernstein BE, Casellas R, Lander ES, Aiden EL. Rao SSP, et al. Among authors: aiden el. Cell. 2017 Oct 5;171(2):305-320.e24. doi: 10.1016/j.cell.2017.09.026. Cell. 2017. PMID: 28985562 Free PMC article.
Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus).
Larsen PA, Harris RA, Liu Y, Murali SC, Campbell CR, Brown AD, Sullivan BA, Shelton J, Brown SJ, Raveendran M, Dudchenko O, Machol I, Durand NC, Shamim MS, Aiden EL, Muzny DM, Gibbs RA, Yoder AD, Rogers J, Worley KC. Larsen PA, et al. Among authors: aiden el. BMC Biol. 2017 Nov 16;15(1):110. doi: 10.1186/s12915-017-0439-6. BMC Biol. 2017. PMID: 29145861 Free PMC article.
85 results