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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R. Janezic S, et al. Among authors: threlfell s. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4016-25. doi: 10.1073/pnas.1309143110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082145 Free PMC article.
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.
Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL. Anwar S, et al. Among authors: threlfell s. J Neurosci. 2011 May 18;31(20):7264-74. doi: 10.1523/JNEUROSCI.6194-10.2011. J Neurosci. 2011. PMID: 21593311 Free PMC article.
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R. Sloan M, et al. Among authors: threlfell s. Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6. Hum Mol Genet. 2016. PMID: 26744332 Free PMC article.
30 results