Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.
Zhang Y, Zhang Q, Chu Z, Chen L, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G, Wang J, Zhu Y.
Zhang Y, et al. Among authors: zhang q.
Chem Commun (Camb). 2022 Nov 29;58(95):13250-13253. doi: 10.1039/d2cc05278d.
Chem Commun (Camb). 2022.
PMID: 36367053