Moran SP - Search Results

1

Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders.

Moran SP, Maksymetz J, Conn PJ. Moran SP, et al. Trends Pharmacol Sci. 2019 Dec;40(12):1006-1020. doi: 10.1016/j.tips.2019.10.007. Epub 2019 Nov 8. Trends Pharmacol Sci. 2019. PMID: 31711626 Free PMC article. Review.

2

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M₁ PAM VU6004256.

Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Grannan MD, et al. Among authors: moran sp. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. doi: 10.1021/acschemneuro.6b00230. Epub 2016 Oct 5. ACS Chem Neurosci. 2016. PMID: 27617634 Free PMC article.

3

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.

Maksymetz J, Moran SP, Conn PJ. Maksymetz J, et al. Among authors: moran sp. Mol Brain. 2017 Apr 26;10(1):15. doi: 10.1186/s13041-017-0293-z. Mol Brain. 2017. PMID: 28446243 Free PMC article. Review.

4

Role of mGlu₅ Receptors and Inhibitory Neurotransmission in M₁ Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.

Ghoshal A, Moran SP, Dickerson JW, Joffe ME, Grueter BA, Xiang Z, Lindsley CW, Rook JM, Conn PJ. Ghoshal A, et al. Among authors: moran sp. ACS Chem Neurosci. 2017 Oct 18;8(10):2254-2265. doi: 10.1021/acschemneuro.7b00167. Epub 2017 Aug 9. ACS Chem Neurosci. 2017. PMID: 28679049 Free PMC article.

5

M₁-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.

Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771. doi: 10.1038/s41386-018-0033-9. Epub 2018 Mar 14. Neuropsychopharmacology. 2018. PMID: 29581537 Free PMC article.

6

PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.

Moran SP, Cho HP, Maksymetz J, Remke DH, Hanson RM, Niswender CM, Lindsley CW, Rook JM, Conn PJ. Moran SP, et al. ACS Chem Neurosci. 2018 Sep 19;9(9):2218-2224. doi: 10.1021/acschemneuro.8b00106. Epub 2018 Apr 25. ACS Chem Neurosci. 2018. PMID: 29683646 Free PMC article.

7

A Novel M₁ PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.

Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW. Rook JM, et al. Among authors: moran sp. ACS Chem Neurosci. 2018 Sep 19;9(9):2274-2285. doi: 10.1021/acschemneuro.8b00131. Epub 2018 May 8. ACS Chem Neurosci. 2018. PMID: 29701957 Free PMC article.

8

M₁ Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.

Maksymetz J, Joffe ME, Moran SP, Stansley BJ, Li B, Temple K, Engers DW, Lawrence JJ, Lindsley CW, Conn PJ. Maksymetz J, et al. Among authors: moran sp. Biol Psychiatry. 2019 Jun 15;85(12):989-1000. doi: 10.1016/j.biopsych.2019.02.020. Epub 2019 Mar 7. Biol Psychiatry. 2019. PMID: 31003787 Free PMC article.

9

Biased M₁ receptor-positive allosteric modulators reveal role of phospholipase D in M₁-dependent rodent cortical plasticity.

Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ. Moran SP, et al. Sci Signal. 2019 Dec 3;12(610):eaax2057. doi: 10.1126/scisignal.aax2057. Sci Signal. 2019. PMID: 31796631 Free PMC article.

10

Leveraging bias to your advantage.

Moran SP, Conn PJ. Moran SP, et al. Nat Chem Biol. 2020 Mar;16(3):226-227. doi: 10.1038/s41589-020-0468-2. Nat Chem Biol. 2020. PMID: 32080631 No abstract available.

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