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The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis.
Manthey CL, Moore BA, Chen Y, Loza MJ, Yao X, Liu H, Belkowski SM, Raymond-Parks H, Dunford PJ, Leon F, Towne JE, Plevy SE. Manthey CL, et al. Among authors: leon f. PLoS One. 2019 Nov 11;14(11):e0223918. doi: 10.1371/journal.pone.0223918. eCollection 2019. PLoS One. 2019. PMID: 31710624 Free PMC article.
Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics.
Porter CK, Riddle MS, Gutierrez RL, Princen F, Strauss R, Telesco SE, Torres J, Choung RS, Laird RM, Leon F, Colombel JF, Murray JA; PREDICTS study team. Porter CK, et al. Among authors: leon f. Contemp Clin Trials Commun. 2019 Mar 26;14:100345. doi: 10.1016/j.conctc.2019.100345. eCollection 2019 Jun. Contemp Clin Trials Commun. 2019. PMID: 30989149 Free PMC article.
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.
Zhuang Y, de Vries DE, Xu Z, Marciniak SJ Jr, Chen D, Leon F, Davis HM, Zhou H. Zhuang Y, et al. Among authors: leon f. J Clin Pharmacol. 2015 Dec;55(12):1386-94. doi: 10.1002/jcph.561. Epub 2015 Jul 29. J Clin Pharmacol. 2015. PMID: 26054042 Clinical Trial.
Flavanones from Miconia prasina.
Tarawneh AH, León F, Ibrahim MA, Pettaway S, McCurdy CR, Cutler SJ. Tarawneh AH, et al. Among authors: leon f. Phytochem Lett. 2014 Feb;7:130-132. doi: 10.1016/j.phytol.2013.11.001. Phytochem Lett. 2014. PMID: 24976876 Free PMC article.
511 results