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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing.
Wang Y, Mittelstaedt RA, Wynne R, Chen Y, Cao X, Muskhelishvili L, Davis K, Robison TW, Sun W, Schmidt EK, Smith TH, Norgaard ZK, Valentine CC, Yaplee J, Williams LN, Salk JJ, Heflich RH. Wang Y, et al. Among authors: robison tw. Environ Mol Mutagen. 2021 Jun;62(5):306-318. doi: 10.1002/em.22444. Epub 2021 Jun 14. Environ Mol Mutagen. 2021. PMID: 34050964 Free PMC article.
Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity.
Robison TW, Heflich RH, Manjanatha MG, Elespuru R, Atrakchi A, Mei N, Ding W. Robison TW, et al. Mutat Res Genet Toxicol Environ Mutagen. 2021 Aug-Sep;868-869:503386. doi: 10.1016/j.mrgentox.2021.503386. Epub 2021 Jul 22. Mutat Res Genet Toxicol Environ Mutagen. 2021. PMID: 34454692
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