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Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA. Brunetti L, et al. Among authors: lin cy. Cancer Cell. 2018 Sep 10;34(3):499-512.e9. doi: 10.1016/j.ccell.2018.08.005. Cancer Cell. 2018. PMID: 30205049 Free PMC article.
Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.
Saenz DT, Fiskus W, Mill CP, Perera D, Manshouri T, Lara BH, Karkhanis V, Sharma S, Horrigan SK, Bose P, Kadia TM, Masarova L, DiNardo CD, Borthakur G, Khoury JD, Takahashi K, Bhaskara S, Lin CY, Green MR, Coarfa C, Crews CM, Verstovsek S, Bhalla KN. Saenz DT, et al. Among authors: lin cy. Blood. 2020 Apr 9;135(15):1255-1269. doi: 10.1182/blood.2019002922. Blood. 2020. PMID: 32068780 Free PMC article.
Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency.
Perez MW, Sias-Garcia O, Daramola A, Wei H, Terrell M, Rashid R, Park WD, Duong K, Horton TM, Li F, Cherayil N, Koren JV, Gant VU, Junco JJ, Curry CV, Stevens AM, Lin CY, Yi JS. Perez MW, et al. Among authors: lin cy. Blood Adv. 2021 Dec 14;5(23):4864-4876. doi: 10.1182/bloodadvances.2020003737. Blood Adv. 2021. PMID: 34543389 Free PMC article.
An oncogenic enhancer encodes selective selenium dependency in AML.
Eagle K, Jiang Y, Shi X, Li M, Obholzer NP, Hu T, Perez MW, Koren JV, Kitano A, Yi JS, Lin CY, Nakada D. Eagle K, et al. Among authors: lin cy. Cell Stem Cell. 2022 Mar 3;29(3):386-399.e7. doi: 10.1016/j.stem.2022.01.003. Epub 2022 Feb 1. Cell Stem Cell. 2022. PMID: 35108519 Free PMC article.
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia.
Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. Harada T, et al. Among authors: lin cy. Genes Dev. 2022 Mar 1;36(5-6):368-389. doi: 10.1101/gad.349284.121. Epub 2022 Mar 17. Genes Dev. 2022. PMID: 35301220 Free PMC article.
An oncogenic enhancer encodes selective selenium dependency in AML.
Eagle K, Jiang Y, Shi X, Li M, Obholzer ND, Hu T, Perez MW, Koren JV, Kitano A, Yi JS, Lin CY, Nakada D. Eagle K, et al. Among authors: lin cy. Cell Stem Cell. 2022 Apr 7;29(4):650. doi: 10.1016/j.stem.2022.03.006. Cell Stem Cell. 2022. PMID: 35395189 Free PMC article. No abstract available.
Transcriptional Plasticity Drives Leukemia Immune Escape.
Eagle K, Harada T, Kalfon J, Perez MW, Heshmati Y, Ewers J, Koren JV, Dempster JM, Kugener G, Paralkar VR, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. Eagle K, et al. Among authors: lin cy. Blood Cancer Discov. 2022 Sep 6;3(5):394-409. doi: 10.1158/2643-3230.BCD-21-0207. Blood Cancer Discov. 2022. PMID: 35709529 Free PMC article.
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer.
Meena JK, Wang JH, Neill NJ, Keough D, Putluri N, Katsonis P, Koire AM, Lee H, Bowling EA, Tyagi S, Orellana M, Dominguez-Vidaña R, Li H, Eagle K, Danan C, Chung HC, Yang AD, Wu W, Kurley SJ, Ho BM, Zoeller JR, Olson CM, Meerbrey KL, Lichtarge O, Sreekumar A, Dacso CC, Guddat LW, Rejman D, Hocková D, Janeba Z, Simon LM, Lin CY, Pillon MC, Westbrook TF. Meena JK, et al. Among authors: lin cy. Cancer Discov. 2024 Sep 4;14(9):1699-1716. doi: 10.1158/2159-8290.CD-22-0649. Cancer Discov. 2024. PMID: 39193992 Free PMC article.
6,709 results