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Page 1
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, Bergner A, Chong E, Döbel S, Egger G, Engelhardt C, Ettmayer P, Fuchs JE, Gerstberger T, Gonnella N, Grimm A, Grondal E, Haddad N, Hopfgartner B, Kousek R, Krawiec M, Kriz M, Lamarre L, Leung J, Mayer M, Patel ND, Simov BP, Reeves JT, Schnitzer R, Schrenk A, Sharps B, Solca F, Stadtmüller H, Tan Z, Wunberg T, Zoephel A, McConnell DB. Engelhardt H, et al. Among authors: gonnella n. J Med Chem. 2019 Nov 27;62(22):10272-10293. doi: 10.1021/acs.jmedchem.9b01169. Epub 2019 Nov 13. J Med Chem. 2019. PMID: 31689114 Free article.
Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.
Reeves JT, Fandrick DR, Tan Z, Song JJ, Rodriguez S, Qu B, Kim S, Niemeier O, Li Z, Byrne D, Campbell S, Chitroda A, DeCroos P, Fachinger T, Fuchs V, Gonnella NC, Grinberg N, Haddad N, Jäger B, Lee H, Lorenz JC, Ma S, Narayanan BA, Nummy LJ, Premasiri A, Roschangar F, Sarvestani M, Shen S, Spinelli E, Sun X, Varsolona RJ, Yee N, Brenner M, Senanayake CH. Reeves JT, et al. Among authors: gonnella nc. J Org Chem. 2013 Apr 19;78(8):3616-35. doi: 10.1021/jo400079z. Epub 2013 Apr 1. J Org Chem. 2013. PMID: 23544738
Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor.
Han ZS, Xu Y, Fandrick DR, Rodriguez S, Li Z, Qu B, Gonnella NC, Sanyal S, Reeves JT, Ma S, Grinberg N, Haddad N, Krishnamurthy D, Song JJ, Yee NK, Pfrengle W, Ostermeier M, Schnaubelt J, Leuter Z, Steigmiller S, Däubler J, Stehle E, Neumann L, Trieselmann T, Tielmann P, Buba A, Hamm R, Koch G, Renner S, Dehli JR, Schmelcher F, Stange C, Mack J, Soyka R, Senanayake CH. Han ZS, et al. Among authors: gonnella nc. Org Lett. 2014 Aug 15;16(16):4142-5. doi: 10.1021/ol501833g. Epub 2014 Aug 1. Org Lett. 2014. PMID: 25084526
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, Wang J, Ma S, Grinberg N, Lee H, Tsantrizos Y, Poupart MA, Busacca CA, Yee NK, Lu BZ, Senanayake CH. Fandrick KR, et al. Among authors: gonnella n. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7144-8. doi: 10.1002/anie.201501575. Epub 2015 May 4. Angew Chem Int Ed Engl. 2015. PMID: 25939331
Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters.
Marsini MA, Reeves JT, Desrosiers JN, Herbage MA, Savoie J, Li Z, Fandrick KR, Sader CA, McKibben B, Gao DA, Cui J, Gonnella NC, Lee H, Wei X, Roschangar F, Lu BZ, Senanayake CH. Marsini MA, et al. Org Lett. 2015 Nov 20;17(22):5614-7. doi: 10.1021/acs.orglett.5b02838. Epub 2015 Nov 11. Org Lett. 2015. PMID: 26558319
Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles.
Malapit CA, Caldwell DR, Luvaga IK, Reeves JT, Volchkov I, Gonnella NC, Han ZS, Busacca CA, Howell AR, Senanayake CH. Malapit CA, et al. Among authors: gonnella nc. Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6999-7002. doi: 10.1002/anie.201703471. Epub 2017 May 11. Angew Chem Int Ed Engl. 2017. PMID: 28493607
47 results