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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. Heichler C, et al. Among authors: pesic m. Gut. 2020 Jul;69(7):1269-1282. doi: 10.1136/gutjnl-2019-319200. Epub 2019 Nov 4. Gut. 2020. PMID: 31685519
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Canli Ö, Nicolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR. Canli Ö, et al. Among authors: pesic m. Cancer Cell. 2017 Dec 11;32(6):869-883.e5. doi: 10.1016/j.ccell.2017.11.004. Cancer Cell. 2017. PMID: 29232557 Free article.
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.
Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR. Varga J, et al. Among authors: pesic m. J Exp Med. 2020 Oct 5;217(10):e20191515. doi: 10.1084/jem.20191515. J Exp Med. 2020. PMID: 32749453 Free PMC article.
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.
Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Nicolas AM, et al. Among authors: pesic m. Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. Cancer Cell. 2022. PMID: 35120600 Free article.
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.
Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Schmitt M, et al. Among authors: pesic m. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. Nature. 2022. PMID: 36385525 Free PMC article.
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade.
Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Conche C, et al. Among authors: pesic m. Gut. 2023 Sep;72(9):1774-1782. doi: 10.1136/gutjnl-2022-327909. Epub 2023 Jan 27. Gut. 2023. PMID: 36707233 Free PMC article.
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer.
Berlin C, Mauerer B, Cauchy P, Luenstedt J, Sankowski R, Marx L, Feuerstein R, Schaefer L, Greten FR, Pesic M, Groß O, Prinz M, Ruehl N, Miketiuk L, Jauch D, Laessle C, Jud A, Biesel EA, Neeff H, Fichtner-Feigl S, Holzner PA, Kesselring R. Berlin C, et al. Among authors: pesic m. J Clin Invest. 2023 Dec 28;134(5):e169576. doi: 10.1172/JCI169576. J Clin Invest. 2023. PMID: 38153787 Free PMC article.
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.
von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. von Knethen A, et al. Among authors: pesic m. Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019. Theranostics. 2019. PMID: 31037153 Free PMC article.
277 results