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Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies.
Azaria RD, Correia AB, Schache KJ, Zapata M, Pathmasiri KC, Mohanty V, Nannapaneni DT, Ashfeld BL, Helquist P, Wiest O, Ohgane K, Li Q, Fredenburg RA, Blagg BS, Cologna SM, Schultz ML, Lieberman AP. Azaria RD, et al. Among authors: ohgane k. JCI Insight. 2024 Aug 29;9(20):e179525. doi: 10.1172/jci.insight.179525. JCI Insight. 2024. PMID: 39207850 Free PMC article.
Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells.
Kabasawa M, Furuta M, Ibayashi Y, Kanemaru K, Kohatsu H, Kuramochi F, Yamatoya K, Nakata K, Nakamura Y, Tomoshige S, Ohgane K, Furuyama Y, Takasawa R, Kobayashi S, Sugawara F, Ikekita M, Kuramochi K. Kabasawa M, et al. Among authors: ohgane k. Bioorg Med Chem Lett. 2024 Sep 15;110:129886. doi: 10.1016/j.bmcl.2024.129886. Epub 2024 Jul 10. Bioorg Med Chem Lett. 2024. PMID: 38996938
A small-molecule degron with a phenylpropionic acid scaffold.
Tomoshige S, Komatsu F, Kikuchi T, Sugiyama M, Kawasaki Y, Ohgane K, Furuyama Y, Sato S, Ishikawa M, Kuramochi K. Tomoshige S, et al. Among authors: ohgane k. Bioorg Med Chem. 2024 Jul 15;109:117789. doi: 10.1016/j.bmc.2024.117789. Epub 2024 Jun 5. Bioorg Med Chem. 2024. PMID: 38870716 Free article.
Anti-hepatitis C Virus Activity of Juglorubin Derivatives.
Ohashi H, Nishioka K, Kurihara T, Nakamura K, Yamasaki M, Ibayashi Y, Fuchiyama K, Kamo S, Furuyama Y, Ohgane K, Okada M, Kamisuki S, Watashi K, Kuramochi K. Ohashi H, et al. Among authors: ohgane k. Chem Pharm Bull (Tokyo). 2023;71(11):843-845. doi: 10.1248/cpb.c23-00489. Chem Pharm Bull (Tokyo). 2023. PMID: 37914261 Free article.
Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A. Noritsugu K, et al. Among authors: ohgane k. Cell Rep. 2023 Apr 25;42(4):112388. doi: 10.1016/j.celrep.2023.112388. Epub 2023 Apr 14. Cell Rep. 2023. PMID: 37060904 Free article.
Synthesis and cytotoxic activities of 8- and 6-demethyleucalyptins.
Asakawa R, Fuchiyama K, Ishii Y, Hosaka K, Kobayashi A, Shimazaki K, Nagasawa J, Tsuchida S, Ushida K, Matsubayashi M, Furuyama Y, Ohgane K, Kuramochi K. Asakawa R, et al. Among authors: ohgane k. Biosci Biotechnol Biochem. 2022 Aug 24;86(9):1200-1206. doi: 10.1093/bbb/zbac105. Biosci Biotechnol Biochem. 2022. PMID: 35776954
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
Hirai K, Yamashita H, Tomoshige S, Mishima Y, Niwa T, Ohgane K, Ishii M, Kanamitsu K, Ikemi Y, Nakagawa S, Taguchi H, Sato S, Hashimoto Y, Ishikawa M. Hirai K, et al. Among authors: ohgane k. ACS Med Chem Lett. 2022 Feb 16;13(3):396-402. doi: 10.1021/acsmedchemlett.1c00500. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300080 Free PMC article.
Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
Nishiuchi K, Ohashi H, Nishioka K, Yamasaki M, Furuta M, Mashiko T, Tomoshige S, Ohgane K, Kamisuki S, Watashi K, Kuramochi K. Nishiuchi K, et al. Among authors: ohgane k. J Nat Prod. 2022 Jan 28;85(1):284-291. doi: 10.1021/acs.jnatprod.1c01120. Epub 2021 Dec 30. J Nat Prod. 2022. PMID: 34967639 Free PMC article.
36 results