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Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.
Garić D, De Sanctis JB, Dumut DC, Shah J, Peña MJ, Youssef M, Petrof BJ, Kopriva F, Hanrahan JW, Hajduch M, Radzioch D. Garić D, et al. Among authors: dumut dc. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158538. doi: 10.1016/j.bbalip.2019.158538. Epub 2019 Oct 31. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31678518
Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease.
Centorame A, Dumut DC, Youssef M, Ondra M, Kianicka I, Shah J, Paun RA, Ozdian T, Hanrahan JW, Gusev E, Petrof B, Hajduch M, Pislariu R, De Sanctis JB, Radzioch D. Centorame A, et al. Among authors: dumut dc. Front Pharmacol. 2022 May 20;13:876842. doi: 10.3389/fphar.2022.876842. eCollection 2022. Front Pharmacol. 2022. PMID: 35668939 Free PMC article.
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