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New synthetic inhibitors of fatty acid synthase with anticancer activity.
Turrado C, Puig T, García-Cárceles J, Artola M, Benhamú B, Ortega-Gutiérrez S, Relat J, Oliveras G, Blancafort A, Haro D, Marrero PF, Colomer R, López-Rodríguez ML. Turrado C, et al. J Med Chem. 2012 Jun 14;55(11):5013-23. doi: 10.1021/jm2016045. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559865
Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, Gómez-Sotres P, Lopez-Fabuel I, Resch-Beusher M, Resel E, Arnouil D, Saraswat D, Varilh M, Cannich A, Julio-Kalajzic F, Bonilla-Del Río I, Almeida A, Puente N, Achicallende S, Lopez-Rodriguez ML, Jollé C, Déglon N, Pellerin L, Josephine C, Bonvento G, Panatier A, Lutz B, Piazza PV, Guzmán M, Bellocchio L, Bouzier-Sore AK, Grandes P, Bolaños JP, Marsicano G. Jimenez-Blasco D, et al. Among authors: lopez rodriguez ml. Nature. 2020 Jul;583(7817):603-608. doi: 10.1038/s41586-020-2470-y. Epub 2020 Jul 8. Nature. 2020. PMID: 32641832
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Veigel D, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, Grusch M, Hegardt FG, García J, Serra D, Auersperg N, Colomer R, Grunt TW. Veigel D, et al. Int J Cancer. 2015 May 1;136(9):2078-90. doi: 10.1002/ijc.29261. Epub 2014 Nov 3. Int J Cancer. 2015. PMID: 25302649 Free article.
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Wagner R, Stübiger G, Veigel D, Wuczkowski M, Lanzerstorfer P, Weghuber J, Karteris E, Nowikovsky K, Wilfinger-Lutz N, Singer CF, Colomer R, Benhamú B, López-Rodríguez ML, Valent P, Grunt TW. Wagner R, et al. Oncotarget. 2017 Feb 14;8(7):11600-11613. doi: 10.18632/oncotarget.14591. Oncotarget. 2017. PMID: 28086243 Free PMC article.
Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity.
Puig T, Turrado C, Benhamú B, Aguilar H, Relat J, Ortega-Gutiérrez S, Casals G, Marrero PF, Urruticoechea A, Haro D, López-Rodríguez ML, Colomer R. Puig T, et al. Clin Cancer Res. 2009 Dec 15;15(24):7608-7615. doi: 10.1158/1078-0432.CCR-09-0856. Clin Cancer Res. 2009. PMID: 20008854
112 results