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Neratinib protects pancreatic beta cells in diabetes.
Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, Yu S, Zhu S, Baguley TD, Surakattula M, Oetjen J, Hauberg-Lotte L, Herranz R, Awal S, Altenhofen D, Nguyen-Tran V, Joseph S, Schultz PG, Chatterjee AK, Rogers N, Tremblay MS, Shen W, Maedler K. Ardestani A, et al. Among authors: maedler k. Nat Commun. 2019 Nov 1;10(1):5015. doi: 10.1038/s41467-019-12880-5. Nat Commun. 2019. PMID: 31676778 Free PMC article.
Interleukin-1 beta targeted therapy for type 2 diabetes.
Maedler K, Dharmadhikari G, Schumann DM, Størling J. Maedler K, et al. Expert Opin Biol Ther. 2009 Sep;9(9):1177-88. doi: 10.1517/14712590903136688. Expert Opin Biol Ther. 2009. PMID: 19604125 Review.
Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.
Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Conte JK, Maedler K. Ardestani A, et al. Among authors: maedler k. J Biol Chem. 2011 May 13;286(19):17144-55. doi: 10.1074/jbc.M110.210526. Epub 2011 Mar 10. J Biol Chem. 2011. Retraction in: J Biol Chem. 2015 Nov 13;290(46):27532. doi: 10.1074/jbc.A110.210526 PMID: 21393239 Free PMC article. Retracted.
TCF7L2 promotes beta cell regeneration in human and mouse pancreas.
Shu L, Zien K, Gutjahr G, Oberholzer J, Pattou F, Kerr-Conte J, Maedler K. Shu L, et al. Among authors: maedler k. Diabetologia. 2012 Dec;55(12):3296-307. doi: 10.1007/s00125-012-2693-z. Epub 2012 Sep 4. Diabetologia. 2012. PMID: 22945304
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Ardestani A, Paroni F, Azizi Z, Kaur S, Khobragade V, Yuan T, Frogne T, Tao W, Oberholzer J, Pattou F, Conte JK, Maedler K. Ardestani A, et al. Among authors: maedler k. Nat Med. 2014 Apr;20(4):385-397. doi: 10.1038/nm.3482. Epub 2014 Mar 16. Nat Med. 2014. PMID: 24633305 Free PMC article.
116 results