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Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.
Novoa EM, Camacho N, Tor A, Wilkinson B, Moss S, Marín-García P, Azcárate IG, Bautista JM, Mirando AC, Francklyn CS, Varon S, Royo M, Cortés A, Ribas de Pouplana L. Novoa EM, et al. Among authors: francklyn cs. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5508-17. doi: 10.1073/pnas.1405994111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489076 Free PMC article.
Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish.
Siekierska A, Stamberger H, Deconinck T, Oprescu SN, Partoens M, Zhang Y, Sourbron J, Adriaenssens E, Mullen P, Wiencek P, Hardies K, Lee JS, Giong HK, Distelmaier F, Elpeleg O, Helbig KL, Hersh J, Isikay S, Jordan E, Karaca E, Kecskes A, Lupski JR, Kovacs-Nagy R, May P, Narayanan V, Pendziwiat M, Ramsey K, Rangasamy S, Shinde DN, Spiegel R, Timmerman V, von Spiczak S, Helbig I; C4RCD Research Group; AR working group of the EuroEPINOMICS RES Consortium; Weckhuysen S, Francklyn C, Antonellis A, de Witte P, De Jonghe P. Siekierska A, et al. Nat Commun. 2019 Feb 12;10(1):708. doi: 10.1038/s41467-018-07953-w. Nat Commun. 2019. PMID: 30755616 Free PMC article.
The catechol moiety of obafluorin is essential for antibacterial activity.
Batey SFD, Davie MJ, Hems ES, Liston JD, Scott TA, Alt S, Francklyn CS, Wilkinson B. Batey SFD, et al. Among authors: francklyn cs. RSC Chem Biol. 2023 Aug 21;4(11):926-941. doi: 10.1039/d3cb00127j. eCollection 2023 Nov 1. RSC Chem Biol. 2023. PMID: 37920400 Free PMC article.
79 results