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Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6.
De Vita E, Smits N, van den Hurk H, Beck EM, Hewitt J, Baillie G, Russell E, Pannifer A, Hamon V, Morrison A, McElroy SP, Jones P, Ignatenko NA, Gunkel N, Miller AK. De Vita E, et al. Among authors: hewitt j. ChemMedChem. 2020 Jan 7;15(1):79-95. doi: 10.1002/cmdc.201900536. Epub 2019 Nov 18. ChemMedChem. 2020. PMID: 31675166 Free PMC article.
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: hewitt j. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Robarge KD, Lee W, Eigenbrot C, Ultsch M, Wiesmann C, Heald R, Price S, Hewitt J, Jackson P, Savy P, Burton B, Choo EF, Pang J, Boggs J, Yang A, Yang X, Baumgardner M. Robarge KD, et al. Among authors: hewitt j. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4714-4723. doi: 10.1016/j.bmcl.2014.08.008. Epub 2014 Aug 15. Bioorg Med Chem Lett. 2014. PMID: 25193232
Delayed return of bowel function after general surgery in South Australia.
Kovoor JG, Bacchi S, Stretton B, Gupta AK, Jacobsen JHW, To MS, Goh R, Hewitt JN, Ovenden CD, Warren L, Marshall-Webb M, Jones KL, Reddi BA, Liew D, Dobbins C, Padbury RT, Hewett PJ, Hugh TJ, Trochsler MI, Maddern GJ. Kovoor JG, et al. Among authors: hewitt jn. Surg Pract Sci. 2024 Jan 10;16:100234. doi: 10.1016/j.sipas.2024.100234. eCollection 2024 Mar. Surg Pract Sci. 2024. PMID: 39845344 Free PMC article.
Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks.
Greco F, Ravenswater HM, Ruiz-Raya F, D'Avino C, Newell MA, Hewitt J, Taylor E, Benninghaus E, Daunt F, Goodman G, Steel D, Park J, Philip E, Thomas SS, Slomka MJ, Falchieri M, Reid SM, James J, Banyard AC, Burthe SJ, Cunningham EJA. Greco F, et al. Among authors: hewitt j. Sci Rep. 2025 Jan 9;15(1):1435. doi: 10.1038/s41598-025-85152-6. Sci Rep. 2025. PMID: 39789128 Free PMC article.
1,373 results