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Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. García-Casarrubios E, et al. Among authors: valverde am. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1929-1941. doi: 10.1016/j.bbalip.2016.09.016. Epub 2016 Sep 26. Biochim Biophys Acta. 2016. PMID: 27686967
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Escalona-Garrido C, Vázquez P, Mera P, Zagmutt S, García-Casarrubios E, Montero-Pedrazuela A, Rey-Stolle F, Guadaño-Ferraz A, Rupérez FJ, Serra D, Herrero L, Obregon MJ, Valverde ÁM. Escalona-Garrido C, et al. Among authors: valverde am. Mol Metab. 2020 Dec;42:101097. doi: 10.1016/j.molmet.2020.101097. Epub 2020 Oct 10. Mol Metab. 2020. PMID: 33049408 Free PMC article.
The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.
Grajales D, Vázquez P, Ruíz-Rosario M, Tudurí E, Mirasierra M, Ferreira V, Hitos AB, Koller D, Zubiaur P, Cigudosa JC, Abad-Santos F, Vallejo M, Quesada I, Tirosh B, Leibowitz G, Valverde ÁM. Grajales D, et al. Among authors: valverde am. Diabetologia. 2022 Mar;65(3):490-505. doi: 10.1007/s00125-021-05630-0. Epub 2021 Dec 21. Diabetologia. 2022. PMID: 34932133 Free PMC article.
Effects of a Mealworm (Tenebrio molitor) Extract on Metabolic Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory Response, Hypolipidemic Activity and Oxidative Stress.
Navarro Del Hierro J, Cantero-Bahillo E, Fernández-Felipe MT, García-Risco MR, Fornari T, Rada P, Doblado L, Ferreira V, Hitos AB, Valverde ÁM, Monsalve M, Martin D. Navarro Del Hierro J, et al. Among authors: valverde am. Insects. 2022 Sep 30;13(10):896. doi: 10.3390/insects13100896. Insects. 2022. PMID: 36292844 Free PMC article.
211 results