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Targeting tauopathy with engineered tau-degrading intrabodies.
Gallardo G, Wong CH, Ricardez SM, Mann CN, Lin KH, Leyns CEG, Jiang H, Holtzman DM. Gallardo G, et al. Among authors: leyns ceg. Mol Neurodegener. 2019 Oct 22;14(1):38. doi: 10.1186/s13024-019-0340-6. Mol Neurodegener. 2019. PMID: 31640765 Free PMC article.
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM. Liao F, et al. J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30. J Clin Invest. 2018. PMID: 29600961 Free PMC article.
Intercellular Spread of Protein Aggregates in Neurodegenerative Disease.
Davis AA, Leyns CEG, Holtzman DM. Davis AA, et al. Among authors: leyns ceg. Annu Rev Cell Dev Biol. 2018 Oct 6;34:545-568. doi: 10.1146/annurev-cellbio-100617-062636. Epub 2018 Jul 25. Annu Rev Cell Dev Biol. 2018. PMID: 30044648 Free PMC article. Review.
New insights into the role of TREM2 in Alzheimer's disease.
Gratuze M, Leyns CEG, Holtzman DM. Gratuze M, et al. Among authors: leyns ceg. Mol Neurodegener. 2018 Dec 20;13(1):66. doi: 10.1186/s13024-018-0298-9. Mol Neurodegener. 2018. PMID: 30572908 Free PMC article. Review.
TREM2 function impedes tau seeding in neuritic plaques.
Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. Leyns CEG, et al. Nat Neurosci. 2019 Aug;22(8):1217-1222. doi: 10.1038/s41593-019-0433-0. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235932 Free PMC article.
16 results