Hou X - Search Results

1

Incorporating Explicit Water Molecules and Ligand Conformation Stability in Machine-Learning Scoring Functions.

Lu J, Hou X, Wang C, Zhang Y. Lu J, et al. Among authors: hou x. J Chem Inf Model. 2019 Nov 25;59(11):4540-4549. doi: 10.1021/acs.jcim.9b00645. Epub 2019 Oct 31. J Chem Inf Model. 2019. PMID: 31638801 Free PMC article.

2

How to improve docking accuracy of AutoDock4.2: a case study using different electrostatic potentials.

Hou X, Du J, Zhang J, Du L, Fang H, Li M. Hou X, et al. J Chem Inf Model. 2013 Jan 28;53(1):188-200. doi: 10.1021/ci300417y. Epub 2013 Jan 2. J Chem Inf Model. 2013. PMID: 23244516

3

Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8.

Hou X, Du J, Liu R, Zhou Y, Li M, Xu W, Fang H. Hou X, et al. J Chem Inf Model. 2015 Apr 27;55(4):861-71. doi: 10.1021/ci500762z. Epub 2015 Mar 16. J Chem Inf Model. 2015. PMID: 25757142

4

Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures.

Hou X, Li K, Yu X, Sun JP, Fang H. Hou X, et al. J Chem Inf Model. 2015 Sep 28;55(9):1973-83. doi: 10.1021/acs.jcim.5b00344. Epub 2015 Sep 17. J Chem Inf Model. 2015. PMID: 26360643

5

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.

Hou X, Rooklin D, Fang H, Zhang Y. Hou X, et al. Sci Rep. 2016 Nov 30;6:38186. doi: 10.1038/srep38186. Sci Rep. 2016. PMID: 27901083 Free PMC article.

6

Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.

Chen C, Hou X, Wang G, Pan W, Yang X, Zhang Y, Fang H. Chen C, et al. Among authors: hou x. Eur J Med Chem. 2017 Jun 16;133:11-23. doi: 10.1016/j.ejmech.2017.03.064. Epub 2017 Mar 28. Eur J Med Chem. 2017. PMID: 28371677

7

Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors.

Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H. Hou X, et al. J Chem Inf Model. 2018 Nov 26;58(11):2331-2342. doi: 10.1021/acs.jcim.8b00548. Epub 2018 Oct 19. J Chem Inf Model. 2018. PMID: 30299094 Free PMC article.

8

Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.

Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun J, Yu X. Li K, et al. Among authors: hou x. J Biol Chem. 2019 May 24;294(21):8653-8663. doi: 10.1074/jbc.RA118.007129. Epub 2019 Apr 12. J Biol Chem. 2019. PMID: 30979725 Free PMC article.

9

Substrate interaction inhibits γ-secretase production of amyloid-β peptides.

Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Zhao J, et al. Among authors: hou x. Chem Commun (Camb). 2020 Feb 27;56(17):2578-2581. doi: 10.1039/c9cc09170j. Chem Commun (Camb). 2020. PMID: 32016207 Free PMC article.

10

Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets.

Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H. Hou X, et al. Eur J Med Chem. 2020 Mar 15;190:112131. doi: 10.1016/j.ejmech.2020.112131. Epub 2020 Feb 11. Eur J Med Chem. 2020. PMID: 32078861 Free PMC article.

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