Sasaki K - Search Results

1

Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.

Yoshida T, Naito Y, Yasuhara H, Sasaki K, Kawaji H, Kawai J, Naito M, Okuda H, Obika S, Inoue T. Yoshida T, et al. Among authors: sasaki k. Genes Cells. 2019 Dec;24(12):827-835. doi: 10.1111/gtc.12730. Epub 2019 Nov 12. Genes Cells. 2019. PMID: 31637814 Free PMC article.

2

Promotion of triplex formation by 2'-O,4'-C-aminomethylene bridged nucleic acid (2',4'-BNA NC) modification.

Sasaki K, Rahman SM, Obika S, Imanishi T, Torigoe H. Sasaki K, et al. Nucleic Acids Symp Ser (Oxf). 2008;(52):419-20. doi: 10.1093/nass/nrn213. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776432

3

Promotion of triplex formation by 3'-amino-2'-O,4'-C-methylene bridged nucleic acid modification.

Sasaki K, Rahman SM, Sato N, Obika S, Imanishi T, Torigoe H. Sasaki K, et al. Nucleic Acids Symp Ser (Oxf). 2009;(53):159-60. doi: 10.1093/nass/nrp080. Nucleic Acids Symp Ser (Oxf). 2009. PMID: 19749309

4

Interrupted 2'-o,4'-C-aminomethylene bridged nucleic acid modification enhances pyrimidine motif triplex-forming ability and nuclease resistance under physiological condition.

Torigoe H, Rahman SM, Takuma H, Sato N, Imanishi T, Obika S, Sasaki K. Torigoe H, et al. Among authors: sasaki k. Nucleosides Nucleotides Nucleic Acids. 2011 Jan;30(1):63-81. doi: 10.1080/15257770.2010.543118. Nucleosides Nucleotides Nucleic Acids. 2011. PMID: 21259164

5

2'-O,4'-C-aminomethylene-bridged nucleic acid modification with enhancement of nuclease resistance promotes pyrimidine motif triplex nucleic acid formation at physiological pH.

Torigoe H, Rahman SM, Takuma H, Sato N, Imanishi T, Obika S, Sasaki K. Torigoe H, et al. Among authors: sasaki k. Chemistry. 2011 Feb 25;17(9):2742-51. doi: 10.1002/chem.201002745. Epub 2011 Jan 24. Chemistry. 2011. PMID: 21264967

6

Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH.

Torigoe H, Nakagawa O, Imanishi T, Obika S, Sasaki K. Torigoe H, et al. Among authors: sasaki k. Biochimie. 2012 Apr;94(4):1032-40. doi: 10.1016/j.biochi.2012.01.003. Epub 2012 Jan 9. Biochimie. 2012. PMID: 22245184

7

Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.

Yamamoto T, Harada-Shiba M, Nakatani M, Wada S, Yasuhara H, Narukawa K, Sasaki K, Shibata MA, Torigoe H, Yamaoka T, Imanishi T, Obika S. Yamamoto T, et al. Among authors: sasaki k. Mol Ther Nucleic Acids. 2012 May 15;1(5):e22. doi: 10.1038/mtna.2012.16. Mol Ther Nucleic Acids. 2012. PMID: 23344002 Free PMC article.

8

Estimated number of off-target candidate sites for antisense oligonucleotides in human mRNA sequences.

Yoshida T, Naito Y, Sasaki K, Uchida E, Sato Y, Naito M, Kawanishi T, Obika S, Inoue T. Yoshida T, et al. Among authors: sasaki k. Genes Cells. 2018 Jun;23(6):448-455. doi: 10.1111/gtc.12587. Epub 2018 Apr 18. Genes Cells. 2018. PMID: 29667281 Free article.

9

Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension.

Yasuhara H, Yoshida T, Sasaki K, Obika S, Inoue T. Yasuhara H, et al. Among authors: sasaki k. Mol Diagn Ther. 2022 Jan;26(1):117-127. doi: 10.1007/s40291-021-00573-z. Epub 2022 Jan 7. Mol Diagn Ther. 2022. PMID: 34994962 Free PMC article.

10

Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.

Yoshida T, Hagihara T, Uchida Y, Horiuchi Y, Sasaki K, Yamamoto T, Yamashita T, Goda Y, Saito Y, Yamaguchi T, Obika S, Yamamoto S, Inoue T. Yoshida T, et al. Among authors: sasaki k. Sci Rep. 2024 May 21;14(1):11540. doi: 10.1038/s41598-024-61666-3. Sci Rep. 2024. PMID: 38773176 Free PMC article.

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