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Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. Tayeb-Fligelman E, et al. Among authors: bowler jt. bioRxiv [Preprint]. 2021 Mar 18:2021.03.05.434000. doi: 10.1101/2021.03.05.434000. bioRxiv. 2021. PMID: 33688654 Free PMC article. Preprint.
De novo designed protein inhibitors of amyloid aggregation and seeding.
Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. Murray KA, et al. Among authors: bowler jt. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206240119. doi: 10.1073/pnas.2206240119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969734 Free PMC article.
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.
Murray KA, Hu CJ, Pan H, Lu J, Abskharon R, Bowler JT, Rosenberg GM, Williams CK, Elezi G, Balbirnie M, Faull KF, Vinters HV, Seidler PM, Eisenberg DS. Murray KA, et al. Among authors: bowler jt. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120. doi: 10.1073/pnas.2217835120. Epub 2023 Feb 9. Proc Natl Acad Sci U S A. 2023. PMID: 36757890 Free PMC article.
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. Tayeb-Fligelman E, et al. Among authors: bowler jt. Nat Commun. 2023 Apr 25;14(1):2379. doi: 10.1038/s41467-023-37865-3. Nat Commun. 2023. PMID: 37185252 Free PMC article.
Reductive debromination of 1,2-dibromides with anisidines.
McGraw KM, Bowler JT, Ly VT, Erden I, Wu W. McGraw KM, et al. Tetrahedron Lett. 2016 Jan 20;57(3):285-287. doi: 10.1016/j.tetlet.2015.11.106. Tetrahedron Lett. 2016. PMID: 26951759 Free PMC article.
Evaluation of benzoic acid derivatives as sirtuin inhibitors.
Chen YP, Catbagan CC, Bowler JT, Gokey T, Goodwin ND, Guliaev AB, Wu W, Amagata T. Chen YP, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):349-52. doi: 10.1016/j.bmcl.2013.11.004. Epub 2013 Nov 12. Bioorg Med Chem Lett. 2014. PMID: 24269123 Free PMC article.
148 results