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Stable Attenuation of Human Respiratory Syncytial Virus for Live Vaccines by Deletion and Insertion of Amino Acids in the Hinge Region between the mRNA Capping and Methyltransferase Domains of the Large Polymerase Protein.
Xue M, Wang R, Harder O, Chen P, Lu M, Cai H, Li A, Liang X, Jennings R, La Perle K, Niewiesk S, Peeples ME, Li J. Xue M, et al. Among authors: harder o. J Virol. 2020 Nov 23;94(24):e01831-20. doi: 10.1128/JVI.01831-20. Print 2020 Nov 23. J Virol. 2020. PMID: 32999025 Free PMC article.
A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque.
Jenkins T, Wang R, Harder O, Xue M, Chen P, Corry J, Walker C, Teng M, Mejias A, Ramilo O, Niewiesk S, Li J, Peeples ME. Jenkins T, et al. Among authors: harder o. J Virol. 2021 Jan 13;95(3):e01568-20. doi: 10.1128/JVI.01568-20. Print 2021 Jan 13. J Virol. 2021. PMID: 33177201 Free PMC article.
CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats.
Green G, Johnson SM, Costello H, Brakel K, Harder O, Oomens AG, Peeples ME, Moulton HM, Niewiesk S. Green G, et al. Among authors: harder o. J Virol. 2021 Jul 26;95(16):e0001021. doi: 10.1128/JVI.00010-21. Epub 2021 Jul 26. J Virol. 2021. PMID: 34037420 Free PMC article.
Coexpression of respiratory syncytial virus (RSV) fusion (F) protein and attachment glycoprotein (G) in a vesicular stomatitis virus (VSV) vector system provides synergistic effects against RSV infection in a cotton rat model.
Brakel KA, Binjawadagi B, French-Kim K, Watts M, Harder O, Ma Y, Li J, Niewiesk S. Brakel KA, et al. Among authors: harder o. Vaccine. 2021 Nov 16;39(47):6817-6828. doi: 10.1016/j.vaccine.2021.10.042. Epub 2021 Oct 23. Vaccine. 2021. PMID: 34702618 Free PMC article.
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
Xue M, Zhang Y, Wang H, Kairis EL, Lu M, Ahmad S, Attia Z, Harder O, Zhang Z, Wei J, Chen P, Gao Y, Peeples ME, Sharma A, Boyaka P, He C, Hur S, Niewiesk S, Li J. Xue M, et al. Among authors: harder o. PLoS Pathog. 2021 Dec 20;17(12):e1010142. doi: 10.1371/journal.ppat.1010142. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34929018 Free PMC article.
28 results