Kannan N - Search Results

1

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.

Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Amatya N, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21539-21544. doi: 10.1073/pnas.1907566116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591208 Free PMC article.

2

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.

Kannan N, Haste N, Taylor SS, Neuwald AF. Kannan N, et al. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1272-7. doi: 10.1073/pnas.0610251104. Epub 2007 Jan 16. Proc Natl Acad Sci U S A. 2007. PMID: 17227859 Free PMC article.

3

Design principles underpinning the regulatory diversity of protein kinases.

Oruganty K, Kannan N. Oruganty K, et al. Among authors: kannan n. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2529-39. doi: 10.1098/rstb.2012.0015. Philos Trans R Soc Lond B Biol Sci. 2012. PMID: 22889905 Free PMC article. Review.

4

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.

Oruganty K, Talathi NS, Wood ZA, Kannan N. Oruganty K, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):924-9. doi: 10.1073/pnas.1207104110. Epub 2012 Dec 31. Proc Natl Acad Sci U S A. 2013. PMID: 23277537 Free PMC article.

5

Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N. Nguyen T, et al. Among authors: kannan n. PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015. PLoS One. 2015. PMID: 25799139 Free PMC article.

6

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Mohanty S, et al. Among authors: kannan n. PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26925779 Free PMC article.

7

Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution.

Kwon A, John M, Ruan Z, Kannan N. Kwon A, et al. Among authors: kannan n. J Biol Chem. 2018 Apr 6;293(14):5102-5116. doi: 10.1074/jbc.RA117.001296. Epub 2018 Feb 12. J Biol Chem. 2018. PMID: 29432127 Free PMC article.

8

Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations.

Ruan Z, Kannan N. Ruan Z, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8162-E8171. doi: 10.1073/pnas.1803152115. Epub 2018 Aug 13. Proc Natl Acad Sci U S A. 2018. PMID: 30104348 Free PMC article.

9

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA. Foulkes DM, et al. Among authors: kannan n. Sci Signal. 2018 Sep 25;11(549):eaat7951. doi: 10.1126/scisignal.aat7951. Sci Signal. 2018. PMID: 30254057 Free PMC article.

10

Tracing the origin and evolution of pseudokinases across the tree of life.

Kwon A, Scott S, Taujale R, Yeung W, Kochut KJ, Eyers PA, Kannan N. Kwon A, et al. Among authors: kannan n. Sci Signal. 2019 Apr 23;12(578):eaav3810. doi: 10.1126/scisignal.aav3810. Sci Signal. 2019. PMID: 31015289 Free PMC article.

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