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Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.
O'Tuathaigh CM, Clarke G, Walsh J, Desbonnet L, Petit E, O'Leary C, Tighe O, Clarke N, Karayiorgou M, Gogos JA, Dinan TG, Cryan JF, Waddington JL. O'Tuathaigh CM, et al. Among authors: tighe o, o leary c. Int J Neuropsychopharmacol. 2012 Oct;15(9):1331-42. doi: 10.1017/S1461145711001581. Epub 2011 Nov 11. Int J Neuropsychopharmacol. 2012. PMID: 22074909 Free article.
Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.
Desbonnet L, O'Tuathaigh C, Clarke G, O'Leary C, Petit E, Clarke N, Tighe O, Lai D, Harvey R, Cryan JF, Dinan TG, Waddington JL. Desbonnet L, et al. Among authors: tighe o. Brain Behav Immun. 2012 May;26(4):660-71. doi: 10.1016/j.bbi.2012.02.010. Epub 2012 Mar 7. Brain Behav Immun. 2012. PMID: 22426432
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.
O'Tuathaigh CM, Fumagalli F, Desbonnet L, Perez-Branguli F, Moloney G, Loftus S, O'Leary C, Petit E, Cox R, Tighe O, Clarke G, Lai D, Harvey RP, Cryan JF, Mitchell KJ, Dinan TG, Riva MA, Waddington JL. O'Tuathaigh CM, et al. Among authors: tighe o. Schizophr Bull. 2017 Jan;43(1):214-225. doi: 10.1093/schbul/sbw120. Epub 2016 Sep 9. Schizophr Bull. 2017. PMID: 27613806 Free PMC article.
Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.
Petit EI, Michalak Z, Cox R, O'Tuathaigh CM, Clarke N, Tighe O, Talbot K, Blake D, Joel J, Shaw A, Sheardown SA, Morrison AD, Wilson S, Shapland EM, Henshall DC, Kew JN, Kirby BP, Waddington JL. Petit EI, et al. Among authors: tighe o. Neuropsychopharmacology. 2017 May;42(6):1349-1360. doi: 10.1038/npp.2016.282. Epub 2016 Dec 16. Neuropsychopharmacology. 2017. PMID: 27986973 Free PMC article.
Ethologically based behavioural and neurochemical characterisation of mice with isoform-specific loss of dysbindin-1A in the context of schizophrenia.
O'Tuathaigh CMP, Desbonnet L, Payne C, Petit E 1st, Cox R, Loftus S, Clarke G, Cryan JF, Tighe O, Wilson S, Kirby BP, Dinan TG, Waddington JL. O'Tuathaigh CMP, et al. Among authors: tighe o. Neurosci Lett. 2020 Sep 25;736:135218. doi: 10.1016/j.neulet.2020.135218. Epub 2020 Jun 29. Neurosci Lett. 2020. PMID: 32615248 Free article.
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.
O'Tuathaigh CM, Hryniewiecka M, Behan A, Tighe O, Coughlan C, Desbonnet L, Cannon M, Karayiorgou M, Gogos JA, Cotter DR, Waddington JL. O'Tuathaigh CM, et al. Among authors: tighe o. Neuropsychopharmacology. 2010 Oct;35(11):2262-73. doi: 10.1038/npp.2010.100. Epub 2010 Jul 14. Neuropsychopharmacology. 2010. PMID: 20631688 Free PMC article.
48 results