Nicolotti O - Search Results

1

Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer's Disease.

Reeta, Baek SC, Lee JP, Rangarajan TM, Ayushee, Singh RP, Singh M, Mangiatordi GF, Nicolotti O, Kim H, Mathew B. Reeta, et al. Among authors: nicolotti o. CNS Neurol Disord Drug Targets. 2019;18(8):643-654. doi: 10.2174/1871527318666190906101326. CNS Neurol Disord Drug Targets. 2019. PMID: 31550216

2

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches.

Catto M, Nicolotti O, Leonetti F, Carotti A, Favia AD, Soto-Otero R, Méndez-Alvarez E, Carotti A. Catto M, et al. Among authors: nicolotti o. J Med Chem. 2006 Aug 10;49(16):4912-25. doi: 10.1021/jm060183l. J Med Chem. 2006. PMID: 16884303

3

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A. Leonetti F, et al. Among authors: nicolotti o. J Med Chem. 2007 Oct 4;50(20):4909-16. doi: 10.1021/jm070725e. Epub 2007 Sep 7. J Med Chem. 2007. PMID: 17824599

4

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.

Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674

5

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Pisani L, Catto M, Giangreco I, Leonetti F, Nicolotti O, Stefanachi A, Cellamare S, Carotti A. Pisani L, et al. Among authors: nicolotti o. ChemMedChem. 2010 Sep 3;5(9):1616-30. doi: 10.1002/cmdc.201000210. ChemMedChem. 2010. PMID: 20677317

6

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.

Tasso B, Catto M, Nicolotti O, Novelli F, Tonelli M, Giangreco I, Pisani L, Sparatore A, Boido V, Carotti A, Sparatore F. Tasso B, et al. Among authors: nicolotti o. Eur J Med Chem. 2011 Jun;46(6):2170-84. doi: 10.1016/j.ejmech.2011.02.071. Epub 2011 Mar 5. Eur J Med Chem. 2011. PMID: 21459491

7

Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases.

Pisani L, Catto M, Leonetti F, Nicolotti O, Stefanachi A, Campagna F, Carotti A. Pisani L, et al. Among authors: nicolotti o. Curr Med Chem. 2011;18(30):4568-87. doi: 10.2174/092986711797379302. Curr Med Chem. 2011. PMID: 21864289 Review.

8

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437843

9

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

Pisani L, Catto M, Nicolotti O, Grossi G, Di Braccio M, Soto-Otero R, Mendez-Alvarez E, Stefanachi A, Gadaleta D, Carotti A. Pisani L, et al. Among authors: nicolotti o. Eur J Med Chem. 2013;70:723-39. doi: 10.1016/j.ejmech.2013.09.034. Epub 2013 Oct 17. Eur J Med Chem. 2013. PMID: 24231308

10

REACH and in silico methods: an attractive opportunity for medicinal chemists.

Nicolotti O, Benfenati E, Carotti A, Gadaleta D, Gissi A, Mangiatordi GF, Novellino E. Nicolotti O, et al. Drug Discov Today. 2014 Nov;19(11):1757-1768. doi: 10.1016/j.drudis.2014.06.027. Epub 2014 Jul 3. Drug Discov Today. 2014. PMID: 24998783 Review.

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