Ory DS - Search Results

1

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.

Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. Lim CY, et al. Among authors: ory ds. Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23. Nat Cell Biol. 2019. PMID: 31548609 Free PMC article.

2

Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.

Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Millard EE, et al. Among authors: ory ds. J Biol Chem. 2000 Dec 8;275(49):38445-51. doi: 10.1074/jbc.M003180200. J Biol Chem. 2000. PMID: 10964915 Free article.

3

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.

Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Frolov A, et al. Among authors: ory ds. J Biol Chem. 2001 Dec 7;276(49):46414-21. doi: 10.1074/jbc.M108099200. Epub 2001 Sep 24. J Biol Chem. 2001. PMID: 11571306 Free article.

4

The niemann-pick disease genes; regulators of cellular cholesterol homeostasis.

Ory DS. Ory DS. Trends Cardiovasc Med. 2004 Feb;14(2):66-72. doi: 10.1016/j.tcm.2003.12.003. Trends Cardiovasc Med. 2004. PMID: 15030792 Review.

5

The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.

Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. Millard EE, et al. Among authors: ory ds. J Biol Chem. 2005 Aug 5;280(31):28581-90. doi: 10.1074/jbc.M414024200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908696 Free article.

6

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.

Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Langmade SJ, et al. Among authors: ory ds. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12. doi: 10.1073/pnas.0606218103. Epub 2006 Aug 29. Proc Natl Acad Sci U S A. 2006. PMID: 16940355 Free PMC article.

7

Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine.

Jiang X, Ory DS, Han X. Jiang X, et al. Among authors: ory ds. Rapid Commun Mass Spectrom. 2007;21(2):141-52. doi: 10.1002/rcm.2820. Rapid Commun Mass Spectrom. 2007. PMID: 17154356 Free PMC article.

8

Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.

Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. Gelsthorpe ME, et al. Among authors: ory ds. J Biol Chem. 2008 Mar 28;283(13):8229-36. doi: 10.1074/jbc.M708735200. Epub 2008 Jan 23. J Biol Chem. 2008. PMID: 18216017 Free PMC article.

9

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.

Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Zhang JR, et al. Among authors: ory ds. J Clin Invest. 2008 Jun;118(6):2281-90. doi: 10.1172/JCI32561. J Clin Invest. 2008. PMID: 18483620 Free PMC article.

10

Getting a "Hold" on NPC2.

Ory DS. Ory DS. Cell Metab. 2009 Sep;10(3):161-2. doi: 10.1016/j.cmet.2009.08.006. Cell Metab. 2009. PMID: 19723490 Free article.

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