Elenius K - Search Results

1

Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation.

Tamirat MZ, Koivu M, Elenius K, Johnson MS. Tamirat MZ, et al. Among authors: elenius k. PLoS One. 2019 Sep 19;14(9):e0222814. doi: 10.1371/journal.pone.0222814. eCollection 2019. PLoS One. 2019. PMID: 31536605 Free PMC article.

2

Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

Tvorogov D, Sundvall M, Kurppa K, Hollmén M, Repo S, Johnson MS, Elenius K. Tvorogov D, et al. Among authors: elenius k. J Biol Chem. 2009 Feb 27;284(9):5582-91. doi: 10.1074/jbc.M805438200. Epub 2008 Dec 19. J Biol Chem. 2009. PMID: 19098003 Free article.

3

Activating ERBB4 mutations in non-small cell lung cancer.

Kurppa KJ, Denessiouk K, Johnson MS, Elenius K. Kurppa KJ, et al. Among authors: elenius k. Oncogene. 2016 Mar 10;35(10):1283-91. doi: 10.1038/onc.2015.185. Epub 2015 Jun 8. Oncogene. 2016. PMID: 26050618

4

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase.

Knittle AM, Helkkula M, Johnson MS, Sundvall M, Elenius K. Knittle AM, et al. Among authors: elenius k. J Biol Chem. 2017 Dec 1;292(48):19890-19904. doi: 10.1074/jbc.M117.794271. Epub 2017 Oct 3. J Biol Chem. 2017. PMID: 28974580 Free PMC article.

5

An unbiased in vitro screen for activating epidermal growth factor receptor mutations.

Chakroborty D, Kurppa KJ, Paatero I, Ojala VK, Koivu M, Tamirat MZ, Koivunen JP, Jänne PA, Johnson MS, Elo LL, Elenius K. Chakroborty D, et al. Among authors: elenius k. J Biol Chem. 2019 Jun 14;294(24):9377-9389. doi: 10.1074/jbc.RA118.006336. Epub 2019 Apr 5. J Biol Chem. 2019. PMID: 30952700 Free PMC article.

6

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation.

Tamirat MZ, Kurppa KJ, Elenius K, Johnson MS. Tamirat MZ, et al. Among authors: elenius k. J Vis Exp. 2020 May 20;(159). doi: 10.3791/61125. J Vis Exp. 2020. PMID: 32510498

7

Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases.

Koivu MKA, Chakroborty D, Tamirat MZ, Johnson MS, Kurppa KJ, Elenius K. Koivu MKA, et al. Among authors: elenius k. Mol Cancer Ther. 2021 Mar;20(3):564-576. doi: 10.1158/1535-7163.MCT-20-0590. Epub 2020 Dec 15. Mol Cancer Ther. 2021. PMID: 33323455 Free article.

8

Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations.

Tamirat MZ, Kurppa KJ, Elenius K, Johnson MS. Tamirat MZ, et al. Among authors: elenius k. Cancers (Basel). 2021 Mar 5;13(5):1120. doi: 10.3390/cancers13051120. Cancers (Basel). 2021. PMID: 33807850 Free PMC article.

9

An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation.

Vaparanta K, Jokilammi A, Tamirat M, Merilahti JAM, Salokas K, Varjosalo M, Ivaska J, Johnson MS, Elenius K. Vaparanta K, et al. Among authors: elenius k. Nat Commun. 2022 Nov 14;13(1):6953. doi: 10.1038/s41467-022-34539-4. Nat Commun. 2022. PMID: 36376313 Free PMC article.

10

An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations.

Chakroborty D, Ojala VK, Knittle AM, Drexler J, Tamirat MZ, Ruzicka R, Bosch K, Woertl J, Schmittner S, Elo LL, Johnson MS, Kurppa KJ, Solca F, Elenius K. Chakroborty D, et al. Among authors: elenius k. Cancer Res Commun. 2022 Jan 7;2(1):10-27. doi: 10.1158/2767-9764.CRC-21-0021. eCollection 2022 Jan. Cancer Res Commun. 2022. PMID: 36860695 Free PMC article.

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