Thummel KE - Search Results

1

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.

Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL. Dalton R, et al. Among authors: thummel ke. Clin Transl Sci. 2020 Jan;13(1):147-156. doi: 10.1111/cts.12695. Epub 2019 Oct 25. Clin Transl Sci. 2020. PMID: 31536170 Free PMC article.

2

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Hartwell PS, Raisys VA, Marsh CL, McVicar JP, Barr DM, et al. Thummel KE, et al. J Pharmacol Exp Ther. 1994 Oct;271(1):549-56. J Pharmacol Exp Ther. 1994. PMID: 7965755

3

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Bacchi CE, Marsh CL, McVicar JP, Barr DM, Perkins JD, et al. Thummel KE, et al. J Pharmacol Exp Ther. 1994 Oct;271(1):557-66. J Pharmacol Exp Ther. 1994. PMID: 7965756

4

Purification of macaque liver flavin-containing monooxygenase: a form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver.

Sadeque AJ, Thummel KE, Rettie AE. Sadeque AJ, et al. Among authors: thummel ke. Biochim Biophys Acta. 1993 Mar 5;1162(1-2):127-34. doi: 10.1016/0167-4838(93)90138-h. Biochim Biophys Acta. 1993. PMID: 8448176

5

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD, Wilkinson GR. Thummel KE, et al. Clin Pharmacol Ther. 1996 May;59(5):491-502. doi: 10.1016/S0009-9236(96)90177-0. Clin Pharmacol Ther. 1996. PMID: 8646820 Clinical Trial.

6

First-pass metabolism of midazolam by the human intestine.

Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JP, Barr DM, Gillies BS, Thummel KE. Paine MF, et al. Among authors: thummel ke. Clin Pharmacol Ther. 1996 Jul;60(1):14-24. doi: 10.1016/S0009-9236(96)90162-9. Clin Pharmacol Ther. 1996. PMID: 8689807

7

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, Perkins JD, Thummel KE. Paine MF, et al. Among authors: thummel ke. J Pharmacol Exp Ther. 1997 Dec;283(3):1552-62. J Pharmacol Exp Ther. 1997. PMID: 9400033

8

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

Gibbs MA, Thummel KE, Shen DD, Kunze KL. Gibbs MA, et al. Among authors: thummel ke. Drug Metab Dispos. 1999 Feb;27(2):180-7. Drug Metab Dispos. 1999. PMID: 9929500

9

Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines.

Madani S, Paine MF, Lewis L, Thummel KE, Shen DD. Madani S, et al. Among authors: thummel ke. Pharm Res. 1999 Aug;16(8):1199-205. doi: 10.1023/a:1018989211864. Pharm Res. 1999. PMID: 10468020

10

Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells.

Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Gibbs MA, et al. Among authors: thummel ke. Pharm Res. 2000 Mar;17(3):299-305. doi: 10.1023/a:1007550717526. Pharm Res. 2000. PMID: 10801218

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