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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.
Pollock KM, Cheeseman HM, McFarlane LR, Day S, Tolazzi M, Turner HL, Joypooranachandran J, Shramko K, Dispinseri S, Mundsperger P, Bontjer I, Lemm NM, Coelho S, Tanaka M, Cole T, Korber B, Katinger D, Sattentau QJ, Ward AB, Scarlatti G, Sanders RW, Shattock RJ. Pollock KM, et al. Among authors: sanders rw. EBioMedicine. 2025 Jan 2;112:105544. doi: 10.1016/j.ebiom.2024.105544. Online ahead of print. EBioMedicine. 2025. PMID: 39753033 Free PMC article.
Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression.
Grobben M, Bakker M, Schriek AI, Levels LJJ, Umotoy JC, Tejjani K, van Breemen MJ, Lin RN, de Taeye SW, Ozorowski G, Kootstra NA, Ward AB, Kent SJ, Hogarth PM, Wines BD, Sanders RW, Chung AW, van Gils MJ. Grobben M, et al. Among authors: sanders rw. PLoS Pathog. 2024 Dec 11;20(12):e1012739. doi: 10.1371/journal.ppat.1012739. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39661636 Free PMC article.
Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
de Taeye SW, Faye L, Morel B, Schriek AI, Umotoy JC, Yuan M, Kuzmina NA, Turner HL, Zhu X, Grünwald-Gruber C, Poniman M, Burger JA, Caniels TG, Fitchette AC, Desgagnés R, Stordeur V, Mirande L, Beauverger G, de Bree G, Ozorowski G, Ward AB, Wilson IA, Bukreyev A, Sanders RW, Vezina LP, Beaumont T, van Gils MJ, Gomord V. de Taeye SW, et al. Among authors: sanders rw. Plant Biotechnol J. 2025 Jan;23(1):4-16. doi: 10.1111/pbi.14458. Epub 2024 Nov 19. Plant Biotechnol J. 2025. PMID: 39563066 Free PMC article.
Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes.
Brinkkemper M, Kerster G, Brouwer PJM, Tran AS, Torres JL, Ettema RA, Nijhuis H, Allen JD, Zhu W, Gao H, Lee WH, Bijl TPL, Snitselaar JL, Burger JA, Bontjer I, Olijhoek W, Ravichandran R, van Breemen MJ, Del Moral-Sánchez I, Derking R, Sliepen K, Ozorowski G, Crispin M, Montefiori DC, Claireaux M, Ward AB, van Gils MJ, King NP, Sanders RW. Brinkkemper M, et al. Among authors: sanders rw. PLoS Pathog. 2024 Oct 3;20(10):e1012558. doi: 10.1371/journal.ppat.1012558. eCollection 2024 Oct. PLoS Pathog. 2024. PMID: 39361585 Free PMC article.
Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses.
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Müller-Kräuter H, Sanders RW, Strecker T, van Gils MJ, Ward AB. Brouwer PJM, et al. Among authors: sanders rw. Cell Rep. 2024 Sep 24;43(9):114708. doi: 10.1016/j.celrep.2024.114708. Epub 2024 Sep 6. Cell Rep. 2024. PMID: 39243373 Free PMC article.
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env.
Agrawal P, Knudsen ML, MacCamy A, Hurlburt NK, Khechaduri A, Salladay KR, Kher GM, Kallur Siddaramaiah L, Stuart AB, Bontjer I, Shen X, Montefiori D, Gristick HB, Bjorkman PJ, Sanders RW, Pancera M, Stamatatos L. Agrawal P, et al. Among authors: sanders rw. J Virol. 2024 Oct 22;98(10):e0074424. doi: 10.1128/jvi.00744-24. Epub 2024 Sep 6. J Virol. 2024. PMID: 39240111 Free PMC article.
450 results