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Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.
Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S. Onitsuka K, et al. Among authors: imoto s. Nucleosides Nucleotides Nucleic Acids. 2020;39(4):518-529. doi: 10.1080/15257770.2019.1664749. Epub 2019 Sep 12. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 31514570 Free PMC article.
Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.
Imoto S, Kohgo S, Tokuda R, Kumamoto H, Aoki M, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K. Imoto S, et al. Nucleosides Nucleotides Nucleic Acids. 2015;34(8):590-602. doi: 10.1080/15257770.2015.1037456. Nucleosides Nucleotides Nucleic Acids. 2015. PMID: 26167667 Free PMC article.
Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.
Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K. Kumamoto H, et al. Among authors: imoto s. J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. J Org Chem. 2016. PMID: 27009432 Free PMC article.
A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.
Kumamoto H, Fukano M, Imoto S, Kohgo S, Odanaka Y, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K, Fukuhara K. Kumamoto H, et al. Among authors: imoto s. Nucleosides Nucleotides Nucleic Acids. 2017 Jul 3;36(7):463-473. doi: 10.1080/15257770.2017.1322209. Epub 2017 Jun 2. Nucleosides Nucleotides Nucleic Acids. 2017. PMID: 28574799 Free PMC article.
CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
Higashi-Kuwata N, Hayashi S, Das D, Kohgo S, Murakami S, Hattori SI, Imoto S, Venzon DJ, Singh K, Sarafianos SG, Tanaka Y, Mitsuya H. Higashi-Kuwata N, et al. Among authors: imoto s. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02143-18. doi: 10.1128/AAC.02143-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30670420 Free PMC article.
849 results