Haraguchi K - Search Results

1

Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.

Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S. Onitsuka K, et al. Among authors: haraguchi k. Nucleosides Nucleotides Nucleic Acids. 2020;39(4):518-529. doi: 10.1080/15257770.2019.1664749. Epub 2019 Sep 12. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 31514570 Free PMC article.

2

Synthesis of 3'alpha-carbo-substituted 2',3'-dideoxyribonucleosides from naturally occurring nucleosides.

Kumamoto H, Tanaka H, Ogamino J, Suzuki H, Haraguchi K, Miyasaka T. Kumamoto H, et al. Among authors: haraguchi k. Nucleic Acids Symp Ser. 1999;(42):1-2. doi: 10.1093/nass/42.1.1. Nucleic Acids Symp Ser. 1999. PMID: 10780349

3

Nucleophilic addition of benzenethiol to 1',2'-unsaturated nucleosides: 1'-C-phenylthio-2'-deoxynucleosides as anomeric radical precursors.

Kumamoto H, Murasaki M, Haraguchi K, Anamura A, Tanaka H. Kumamoto H, et al. Among authors: haraguchi k. J Org Chem. 2002 Aug 23;67(17):6124-30. doi: 10.1021/jo0201934. J Org Chem. 2002. PMID: 12182652

4

Development of radioiodinated nucleoside analogs for imaging tissue proliferation: comparisons of six 5-iodonucleosides.

Toyohara J, Hayashi A, Sato M, Gogami A, Tanaka H, Haraguchi K, Yoshimura Y, Kumamoto H, Yonekura Y, Fujibayashi Y. Toyohara J, et al. Among authors: haraguchi k. Nucl Med Biol. 2003 Oct;30(7):687-96. doi: 10.1016/s0969-8051(03)00081-7. Nucl Med Biol. 2003. PMID: 14499326

5

Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.

Haraguchi K, Itoh Y, Takeda S, Honma Y, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Haraguchi K, et al. Nucleosides Nucleotides Nucleic Acids. 2004;23(4):647-54. doi: 10.1081/NCN-120030721. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15200028

6

5-Exo versus 6-endo cyclization of nucleoside 2-sila-5-hexenyl radicals: reaction of 6-(bromomethyl)dimethylsilyl 1',2'-unsaturated uridines.

Ogamino J, Mizunuma H, Kumamoto H, Takeda S, Haraguchi K, Nakamura KT, Sugiyama H, Tanaka H. Ogamino J, et al. Among authors: haraguchi k. J Org Chem. 2005 Mar 4;70(5):1684-90. doi: 10.1021/jo040260p. J Org Chem. 2005. PMID: 15730288

7

Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T).

Kumamoto H, Haraguchi K, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC, Kato K. Kumamoto H, et al. Among authors: haraguchi k. Nucleosides Nucleotides Nucleic Acids. 2005;24(2):73-83. doi: 10.1081/NCN-51900. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 15822615

8

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

Nitanda T, Wang X, Kumamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M. Nitanda T, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2005 Aug;49(8):3355-60. doi: 10.1128/AAC.49.8.3355-3360.2005. Antimicrob Agents Chemother. 2005. PMID: 16048947 Free PMC article.

9

4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.

Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. Tanaka H, et al. Among authors: haraguchi k. Antivir Chem Chemother. 2005;16(4):217-21. doi: 10.1177/095632020501600402. Antivir Chem Chemother. 2005. PMID: 16130520 Free article.

10

A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Sumino M, Tanaka H, Dutschman GE, Cheng YC, Nitanda T, Baba M. Haraguchi K, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):343-7. doi: 10.1081/ncn-200059774. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247949

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