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Page 1
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD. Samir P, et al. Among authors: kesavardhana s. Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11. Nature. 2019. PMID: 31511697 Free PMC article.
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD. Man SM, et al. Among authors: kesavardhana s. Cell. 2016 Oct 6;167(2):382-396.e17. doi: 10.1016/j.cell.2016.09.012. Epub 2016 Sep 29. Cell. 2016. PMID: 27693356 Free PMC article.
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Karki R, Man SM, Malireddi RKS, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD. Karki R, et al. Among authors: kesavardhana s. Nature. 2016 Dec 22;540(7634):583-587. doi: 10.1038/nature20597. Epub 2016 Dec 12. Nature. 2016. PMID: 27951586 Free PMC article.
Stressed-out ROS take a silent death route.
Kesavardhana S, Kanneganti TD. Kesavardhana S, et al. Nat Immunol. 2018 Feb;19(2):103-105. doi: 10.1038/s41590-017-0034-6. Nat Immunol. 2018. PMID: 29348507 No abstract available.
33 results