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Page 1
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach.
Drowley L, McPheat J, Nordqvist A, Peel S, Karlsson U, Martinsson S, Müllers E, Dellsén A, Knight S, Barrett I, Sánchez J, Magnusson B, Greber B, Wang QD, Plowright AT. Drowley L, et al. Among authors: barrett i. Stem Cells Transl Med. 2020 Jan;9(1):47-60. doi: 10.1002/sctm.19-0069. Epub 2019 Sep 11. Stem Cells Transl Med. 2020. PMID: 31508905 Free PMC article.
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.
Woo LA, Tkachenko S, Ding M, Plowright AT, Engkvist O, Andersson H, Drowley L, Barrett I, Firth M, Akerblad P, Wolf MJ, Bekiranov S, Brautigan DL, Wang QD, Saucerman JJ. Woo LA, et al. Among authors: barrett i. J Mol Cell Cardiol. 2019 Feb;127:204-214. doi: 10.1016/j.yjmcc.2018.12.015. Epub 2018 Dec 28. J Mol Cell Cardiol. 2019. PMID: 30597148 Free PMC article.
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.
Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, Ding M, Andersson H, Polla M, Elliott DA, Drowley L, Clausen M, Plowright AT, Barrett IP, Wang QD, James DE, Porrello ER, Hudson JE. Mills RJ, et al. Cell Stem Cell. 2019 Jun 6;24(6):895-907.e6. doi: 10.1016/j.stem.2019.03.009. Epub 2019 Mar 28. Cell Stem Cell. 2019. PMID: 30930147 Free article.
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature.
Trapotsi MA, Mouchet E, Williams G, Monteverde T, Juhani K, Turkki R, Miljković F, Martinsson A, Mervin L, Pryde KR, Müllers E, Barrett I, Engkvist O, Bender A, Moreau K. Trapotsi MA, et al. Among authors: barrett i. ACS Chem Biol. 2022 Jul 15;17(7):1733-1744. doi: 10.1021/acschembio.2c00076. Epub 2022 Jul 6. ACS Chem Biol. 2022. PMID: 35793809 Free PMC article.
Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate the small molecule induction of human iPSC-derived cardiomyocyte proliferation.
Woo LA, Wintruba KL, Wissmann B, Tkachenko S, Kubicka E, Farber E, Engkvist O, Barrett I, Granberg KL, Plowright AT, Wolf MJ, Brautigan DL, Bekiranov S, Wang QD, Saucerman JJ. Woo LA, et al. Among authors: barrett i. iScience. 2024 Jul 11;27(8):110485. doi: 10.1016/j.isci.2024.110485. eCollection 2024 Aug 16. iScience. 2024. PMID: 39171295 Free PMC article.
Orthologue chemical space and its influence on target prediction.
Mervin LH, Bulusu KC, Kalash L, Afzal AM, Svensson F, Firth MA, Barrett I, Engkvist O, Bender A. Mervin LH, et al. Among authors: barrett i. Bioinformatics. 2018 Jan 1;34(1):72-79. doi: 10.1093/bioinformatics/btx525. Bioinformatics. 2018. PMID: 28961699 Free PMC article.
118 results