Howe MK - Search Results

1

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase.

Howe MK, Dowdell K, Roy A, Niemela JE, Wilson W, McElwee JJ, Hughes JD, Cohen JI. Howe MK, et al. Front Immunol. 2019 Aug 27;10:2000. doi: 10.3389/fimmu.2019.02000. eCollection 2019. Front Immunol. 2019. PMID: 31507602 Free PMC article.

2

Patients With Natural Killer (NK) Cell Chronic Active Epstein-Barr Virus Have Immature NK Cells and Hyperactivation of PI3K/Akt/mTOR and STAT1 Pathways.

Howe MK, Dowdell K, Kuehn HS, Li Q, Hart GT, Garabedian D, Liepshutz K, Hsu AP, Su H, Niemela JE, Stoddard JL, Uzel G, Shereck E, Schulz L, Feldman T, Rosenzweig SD, Long EO, Dropulic L, Cohen JI. Howe MK, et al. J Infect Dis. 2020 Sep 1;222(7):1170-1179. doi: 10.1093/infdis/jiaa232. J Infect Dis. 2020. PMID: 32386415 Free PMC article.

3

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.

Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92. doi: 10.1016/j.antiviral.2016.03.017. Epub 2016 Apr 4. Antiviral Res. 2016. PMID: 27058774 Free PMC article.

4

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11. Chem Biol. 2014. PMID: 25500222 Free PMC article.

5

CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.

Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. Frigo DE, et al. Among authors: howe mk. Cancer Res. 2011 Jan 15;71(2):528-37. doi: 10.1158/0008-5472.CAN-10-2581. Epub 2010 Nov 22. Cancer Res. 2011. PMID: 21098087 Free PMC article.

6

Androgens promote prostate cancer cell growth through induction of autophagy.

Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Shi Y, et al. Among authors: howe mk. Mol Endocrinol. 2013 Feb;27(2):280-95. doi: 10.1210/me.2012-1260. Epub 2012 Dec 18. Mol Endocrinol. 2013. PMID: 23250485 Free PMC article.

7

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. Nelson ER, et al. Among authors: howe mk. Science. 2013 Nov 29;342(6162):1094-8. doi: 10.1126/science.1241908. Science. 2013. PMID: 24288332 Free PMC article.

8

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.

Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. Nelson ER, et al. Among authors: howe mk. Endocrinology. 2011 Dec;152(12):4691-705. doi: 10.1210/en.2011-1298. Epub 2011 Sep 20. Endocrinology. 2011. PMID: 21933863 Free PMC article.

9

Validation of a death assay for Angiostrongylus cantonensis larvae (L3) using propidium iodide in a rat model (Rattus norvegicus).

Jarvi SI, Jacob J, Sugihara RT, Leinbach IL, Klasner IH, Kaluna LM, Snook KA, Howe MK, Jacquier SH, Lange I, Atkinson AL, Deane AR, Niebuhr CN, Siers SR. Jarvi SI, et al. Among authors: howe mk. Parasitology. 2019 Sep;146(11):1421-1428. doi: 10.1017/S0031182019000908. Epub 2019 Jul 31. Parasitology. 2019. PMID: 31267883

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