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A single combination gene therapy treats multiple age-related diseases.
Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, Punthambaker S, Sun X, Liao R, Bonventre JV, Church GM. Davidsohn N, et al. Among authors: bonventre jv. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23505-23511. doi: 10.1073/pnas.1910073116. Epub 2019 Nov 4. Proc Natl Acad Sci U S A. 2019. PMID: 31685628 Free PMC article.
Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis.
Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV. Li L, et al. Among authors: bonventre jv. EMBO Rep. 2021 Jun 4;22(6):e51169. doi: 10.15252/embr.202051169. Epub 2021 May 25. EMBO Rep. 2021. PMID: 34031962 Free PMC article.
Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration.
Ajay AK, Zhao L, Vig S, Fujiwara M, Thakurela S, Jadhav S, Cho A, Chiu IJ, Ding Y, Ramachandran K, Mithal A, Bhatt A, Chaluvadi P, Gupta MK, Shah SI, Sabbisetti VS, Waaga-Gasser AM, Frank DA, Murugaiyan G, Bonventre JV, Hsiao LL. Ajay AK, et al. Among authors: bonventre jv. Cell Rep. 2022 Mar 8;38(10):110473. doi: 10.1016/j.celrep.2022.110473. Cell Rep. 2022. PMID: 35263586 Free PMC article.
542 results