Kudolo M - Search Results

1

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

Astolfi A, Kudolo M, Brea J, Manni G, Manfroni G, Palazzotti D, Sabatini S, Cecchetti F, Felicetti T, Cannalire R, Massari S, Tabarrini O, Loza MI, Fallarino F, Cecchetti V, Laufer SA, Barreca ML. Astolfi A, et al. Among authors: kudolo m. Eur J Med Chem. 2019 Nov 15;182:111624. doi: 10.1016/j.ejmech.2019.111624. Epub 2019 Aug 16. Eur J Med Chem. 2019. PMID: 31445234

2

Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.

Heider F, Ansideri F, Tesch R, Pantsar T, Haun U, Döring E, Kudolo M, Poso A, Albrecht W, Laufer SA, Koch P. Heider F, et al. Among authors: kudolo m. Eur J Med Chem. 2019 Aug 1;175:309-329. doi: 10.1016/j.ejmech.2019.04.035. Epub 2019 Apr 24. Eur J Med Chem. 2019. PMID: 31096153

3

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.

Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Müller G, Tesch R, Kudolo M, Forster M, Laufer S, Knapp S. Röhm S, et al. Among authors: kudolo m. J Med Chem. 2019 Dec 12;62(23):10757-10782. doi: 10.1021/acs.jmedchem.9b01227. Epub 2019 Nov 26. J Med Chem. 2019. PMID: 31702918

4

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Pedreira JGB, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer S, Barreiro EJ. Pedreira JGB, et al. Among authors: kudolo m. J Med Chem. 2020 Jul 9;63(13):7347-7354. doi: 10.1021/acs.jmedchem.0c00508. Epub 2020 Jun 11. J Med Chem. 2020. PMID: 32462866

5

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S. Röhm S, et al. Among authors: kudolo m. Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20. Eur J Med Chem. 2020. PMID: 33035818

6

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.

Pantsar T, Kaiser PD, Kudolo M, Forster M, Rothbauer U, Laufer SA. Pantsar T, et al. Among authors: kudolo m. Nat Commun. 2022 Jan 28;13(1):569. doi: 10.1038/s41467-022-28164-4. Nat Commun. 2022. PMID: 35091547 Free PMC article.

7

Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.

Dimitrov T, Anli C, Moschopoulou AA, Kronenberger T, Kudolo M, Geibel C, Schwalm MP, Knapp S, Zender L, Forster M, Laufer S. Dimitrov T, et al. Among authors: kudolo m. Eur J Med Chem. 2022 May 5;235:114234. doi: 10.1016/j.ejmech.2022.114234. Epub 2022 Mar 8. Eur J Med Chem. 2022. PMID: 35325634

8

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Ansideri F, Kudolo M, Forster M, Schollmeyer D, Laufer SA, Koch P. Andreev S, et al. Among authors: kudolo m. Molecules. 2019 Jun 25;24(12):2331. doi: 10.3390/molecules24122331. Molecules. 2019. PMID: 31242571 Free PMC article.

9

Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks.

Heider F, Pantsar T, Kudolo M, Ansideri F, De Simone A, Pruccoli L, Schneider T, Goettert MI, Tarozzi A, Andrisano V, Laufer SA, Koch P. Heider F, et al. Among authors: kudolo m. ACS Med Chem Lett. 2019 Aug 26;10(10):1407-1414. doi: 10.1021/acsmedchemlett.9b00177. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620226 Free PMC article.

10

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Andreev S, Pantsar T, El-Gokha A, Ansideri F, Kudolo M, Anton DB, Sita G, Romasco J, Geibel C, Lämmerhofer M, Goettert MI, Tarozzi A, Laufer SA, Koch P. Andreev S, et al. Among authors: kudolo m. Int J Mol Sci. 2020 Oct 22;21(21):7823. doi: 10.3390/ijms21217823. Int J Mol Sci. 2020. PMID: 33105671 Free PMC article.

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