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Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil.
Carnielli JBT, Monti-Rocha R, Costa DL, Molina Sesana A, Pansini LNN, Segatto M, Mottram JC, Costa CHN, Carvalho SFG, Dietze R. Carnielli JBT, et al. Among authors: mottram jc. Am J Trop Med Hyg. 2019 Oct;101(4):789-794. doi: 10.4269/ajtmh.18-0949. Am J Trop Med Hyg. 2019. PMID: 31436148 Free PMC article. Clinical Trial.
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival.
Baker N, Catta-Preta CMC, Neish R, Sadlova J, Powell B, Alves-Ferreira EVC, Geoghegan V, Carnielli JBT, Newling K, Hughes C, Vojtkova B, Anand J, Mihut A, Walrad PB, Wilson LG, Pitchford JW, Volf P, Mottram JC. Baker N, et al. Among authors: mottram jc. Nat Commun. 2021 Feb 23;12(1):1244. doi: 10.1038/s41467-021-21360-8. Nat Commun. 2021. PMID: 33623024 Free PMC article.
Candidates for Balancing Selection in Leishmania donovani Complex Parasites.
Grace CA, Forrester S, Silva VC, Carvalho KSS, Kilford H, Chew YP, James S, Costa DL, Mottram JC, Costa CCHN, Jeffares DC. Grace CA, et al. Among authors: mottram jc. Genome Biol Evol. 2021 Dec 1;13(12):evab265. doi: 10.1093/gbe/evab265. Genome Biol Evol. 2021. PMID: 34865011 Free PMC article.
Bromodomain factor 5 is an essential regulator of transcription in Leishmania.
Jones NG, Geoghegan V, Moore G, Carnielli JBT, Newling K, Calderón F, Gabarró R, Martín J, Prinjha RK, Rioja I, Wilkinson AJ, Mottram JC. Jones NG, et al. Among authors: mottram jc. Nat Commun. 2022 Jul 13;13(1):4071. doi: 10.1038/s41467-022-31742-1. Nat Commun. 2022. PMID: 35831302 Free PMC article.
Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis.
Grace CA, Sousa Carvalho KS, Sousa Lima MI, Costa Silva V, Reis-Cunha JL, Brune MJ, Forrester S, Pedrozo E Silva de Azevedo CM, Costa DL, Speed D, Mottram JC, Jeffares DC, Costa CHN. Grace CA, et al. Among authors: mottram jc. mBio. 2022 Dec 20;13(6):e0206822. doi: 10.1128/mbio.02068-22. Epub 2022 Oct 12. mBio. 2022. PMID: 36222512 Free PMC article.
Neutrophil elastase promotes Leishmania donovani infection via interferon-β.
Dias BT, Dias-Teixeira KL, Godinho JP, Faria MS, Calegari-Silva T, Mukhtar MM, Lopes U, Mottram JC, Lima APCA. Dias BT, et al. Among authors: mottram jc. FASEB J. 2019 Oct;33(10):10794-10807. doi: 10.1096/fj.201900524R. Epub 2019 Jul 5. FASEB J. 2019. PMID: 31284755 Free PMC article.
263 results