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Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy.
Das B, Okamoto K, Rabalais J, Kozan PA, Marchelletta RR, McGeough MD, Durali N, Go M, Barrett KE, Das S, Sivagnanam M. Das B, et al. Among authors: mcgeough md. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G580-G591. doi: 10.1152/ajpgi.00098.2019. Epub 2019 Aug 21. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31433211 Free PMC article.
Functional consequences of EpCam mutation in mice and men.
Mueller JL, McGeough MD, Peña CA, Sivagnanam M. Mueller JL, et al. Among authors: mcgeough md. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G278-88. doi: 10.1152/ajpgi.00286.2013. Epub 2013 Dec 12. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24337010 Free PMC article.
Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.
Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M. Kozan PA, et al. Among authors: mcgeough md. J Mol Med (Berl). 2015 May;93(5):535-45. doi: 10.1007/s00109-014-1239-x. Epub 2014 Dec 9. J Mol Med (Berl). 2015. PMID: 25482158 Free PMC article.
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. Broderick L, et al. Among authors: mcgeough md. Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6. Nat Commun. 2019. PMID: 31409799 Free PMC article.
NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. Qu C, et al. Among authors: mcgeough md. FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4. FASEB J. 2015. PMID: 25477279 Free PMC article.
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.
Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH. Das S, et al. Among authors: mcgeough md. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137. doi: 10.1073/pnas.1610433113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799535 Free PMC article.
27 results