Brown M - Search Results

1

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.

Smithen DA, Leung LMH, Challinor M, Lawrence R, Tang H, Niculescu-Duvaz D, Pearce SP, Mcleary R, Lopes F, Aljarah M, Brown M, Johnson L, Thomson G, Marais R, Springer C. Smithen DA, et al. Among authors: brown m. J Med Chem. 2020 Mar 12;63(5):2308-2324. doi: 10.1021/acs.jmedchem.9b01112. Epub 2019 Sep 4. J Med Chem. 2020. PMID: 31430136 Free PMC article.

2

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.

Leung L, Niculescu-Duvaz D, Smithen D, Lopes F, Callens C, McLeary R, Saturno G, Davies L, Aljarah M, Brown M, Johnson L, Zambon A, Chambers T, Ménard D, Bayliss N, Knight R, Fish L, Lawrence R, Challinor M, Tang H, Marais R, Springer C. Leung L, et al. Among authors: brown m. J Med Chem. 2019 Jun 27;62(12):5863-5884. doi: 10.1021/acs.jmedchem.9b00335. Epub 2019 May 23. J Med Chem. 2019. PMID: 31070916 Free PMC article.

3

Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow.

Brown M, Aljarah M, Asiki H, Leung LMH, Smithen DA, Miller N, Nemeth G, Davies L, Niculescu-Duvaz D, Zambon A, Springer C. Brown M, et al. Org Process Res Dev. 2021 Jan 15;25(1):148-156. doi: 10.1021/acs.oprd.0c00361. Epub 2020 Oct 15. Org Process Res Dev. 2021. PMID: 33679122 Free PMC article.

4

Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.

Marsham PR, Wardleworth JM, Boyle FT, Hennequin LF, Kimbell R, Brown M, Jackman AL. Marsham PR, et al. Among authors: brown m. J Med Chem. 1999 Sep 23;42(19):3809-20. doi: 10.1021/jm9803727. J Med Chem. 1999. PMID: 10508430

5

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR. Jackman AL, et al. Among authors: brown m. Cancer Res. 1991 Oct 15;51(20):5579-86. Cancer Res. 1991. PMID: 1913676

6

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.

Jackman AL, Kimbell R, Brown M, Brunton L, Bisset GM, Bavetsias V, Marsham P, Hughes LR, Boyle FT. Jackman AL, et al. Among authors: brown m. Anticancer Drug Des. 1995 Oct;10(7):573-89. Anticancer Drug Des. 1995. PMID: 7495480

7

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.

Jackman AL, Kimbell R, Brown M, Brunton L, Boyle FT. Jackman AL, et al. Among authors: brown m. Anticancer Drug Des. 1995 Oct;10(7):555-72. Anticancer Drug Des. 1995. PMID: 7495479

8

Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.

Boyle FT, Matusiak ZS, Hughes LR, Slater AM, Stephens TC, Smith MN, Brown M, Kimbell R, Jackman AL. Boyle FT, et al. Among authors: brown m. Adv Exp Med Biol. 1993;338:585-8. doi: 10.1007/978-1-4615-2960-6_119. Adv Exp Med Biol. 1993. PMID: 8304185 No abstract available.

9

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.

Jackman AL, Kelland LR, Kimbell R, Brown M, Gibson W, Aherne GW, Hardcastle A, Boyle FT. Jackman AL, et al. Among authors: brown m. Br J Cancer. 1995 May;71(5):914-24. doi: 10.1038/bjc.1995.178. Br J Cancer. 1995. PMID: 7537518 Free PMC article.

10

The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.

Jackman AL, Kimbell R, Brown M, Brunton L, Harrap KR, Wardleworth JM, Boyle FT. Jackman AL, et al. Among authors: brown m. Adv Exp Med Biol. 1994;370:185-8. doi: 10.1007/978-1-4615-2584-4_40. Adv Exp Med Biol. 1994. PMID: 7660886 Review. No abstract available.

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