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Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer.
El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Vishvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. El-Kenawi A, et al. Br J Cancer. 2019 Oct;121(7):556-566. doi: 10.1038/s41416-019-0542-2. Epub 2019 Aug 16. Br J Cancer. 2019. PMID: 31417189 Free PMC article.
Accelerating the development of genetically engineered cellular therapies: a framework for extrapolating data across related products.
Stewart MD, Kalos M, Coutinho V, Better M, Jazayeri J, Yohrling J, Jadlowsky J, Fuchs M, Gidwani S, Goessl C, Hanley PJ, Healy J, Liu W, McKelvey BA, Pearce L, Pilon-Thomas S, Andrews HS, Veldman M, Vong J, Weinbach SP, Allen JD. Stewart MD, et al. Among authors: pilon thomas s. Cytotherapy. 2024 Jul;26(7):778-784. doi: 10.1016/j.jcyt.2024.03.009. Epub 2024 Mar 16. Cytotherapy. 2024. PMID: 38583170 Free article.
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.
Pilon-Thomas S, Kodumudi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mulé JJ, Ibrahim-Hashim A, Gillies RJ. Pilon-Thomas S, et al. Cancer Res. 2016 Mar 15;76(6):1381-90. doi: 10.1158/0008-5472.CAN-15-1743. Epub 2015 Dec 30. Cancer Res. 2016. PMID: 26719539 Free PMC article.
Tipping the Balancing ACT.
Pilon-Thomas S, Ruffell B. Pilon-Thomas S, et al. Cancer Cell. 2016 Sep 12;30(3):367-368. doi: 10.1016/j.ccell.2016.08.012. Cancer Cell. 2016. PMID: 27622327 Free article.
Hypoxia and acidosis: immune suppressors and therapeutic targets.
Damgaci S, Ibrahim-Hashim A, Enriquez-Navas PM, Pilon-Thomas S, Guvenis A, Gillies RJ. Damgaci S, et al. Immunology. 2018 Jul;154(3):354-362. doi: 10.1111/imm.12917. Epub 2018 Mar 30. Immunology. 2018. PMID: 29485185 Free PMC article. Review.
Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer.
Poch M, Hall M, Joerger A, Kodumudi K, Beatty M, Innamarato PP, Bunch BL, Fishman MN, Zhang J, Sexton WJ, Pow-Sang JM, Gilbert SM, Spiess PE, Dhillon J, Kelley L, Mullinax J, Sarnaik AA, Pilon-Thomas S. Poch M, et al. Oncoimmunology. 2018 Jul 23;7(9):e1476816. doi: 10.1080/2162402X.2018.1476816. eCollection 2018. Oncoimmunology. 2018. PMID: 30228944 Free PMC article.
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. Mohamed E, et al. Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004. Immunity. 2020. PMID: 32294407 Free PMC article.
Anti-tumor efficacy of plasmid encoding emm55 in a murine melanoma model.
Bunch BL, Kodumudi KN, Scott E, Morse J, Weber AM, Berglund AE, Pilon-Thomas S, Markowitz J. Bunch BL, et al. Cancer Immunol Immunother. 2020 Dec;69(12):2465-2476. doi: 10.1007/s00262-020-02634-4. Epub 2020 Jun 18. Cancer Immunol Immunother. 2020. PMID: 32556443 Free PMC article.
T-cells produce acidic niches in lymph nodes to suppress their own effector functions.
Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ. Wu H, et al. Nat Commun. 2020 Aug 17;11(1):4113. doi: 10.1038/s41467-020-17756-7. Nat Commun. 2020. PMID: 32807791 Free PMC article.
92 results