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The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Daniel B, Czimmerer Z, Halasz L, Boto P, Kolostyak Z, Poliska S, Berger WK, Tzerpos P, Nagy G, Horvath A, Hajas G, Cseh T, Nagy A, Sauer S, Francois-Deleuze J, Szatmari I, Bacsi A, Nagy L. Daniel B, et al. Among authors: halasz l. Genes Dev. 2020 Nov 1;34(21-22):1474-1492. doi: 10.1101/gad.343038.120. Epub 2020 Oct 15. Genes Dev. 2020. PMID: 33060136 Free PMC article.
The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands.
Czimmerer Z, Halasz L, Daniel B, Varga Z, Bene K, Domokos A, Hoeksema M, Shen Z, Berger WK, Cseh T, Jambrovics K, Kolostyak Z, Fenyvesi F, Varadi J, Poliska S, Hajas G, Szatmari I, Glass CK, Bacsi A, Nagy L. Czimmerer Z, et al. Among authors: halasz l. Immunity. 2022 Nov 8;55(11):2006-2026.e6. doi: 10.1016/j.immuni.2022.10.004. Epub 2022 Nov 1. Immunity. 2022. PMID: 36323312 Free PMC article.
Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics.
Melo N, Belyaeva OV, Berger WK, Halasz L, Yu J, Pilli N, Yang Z, Klyuyeva AV, Elmets CA, Atigadda V, Muccio DD, Kane MA, Nagy L, Kedishvili NY, Renfrow MB. Melo N, et al. Among authors: halasz l. J Biol Chem. 2023 Jan;299(1):102746. doi: 10.1016/j.jbc.2022.102746. Epub 2022 Nov 24. J Biol Chem. 2023. PMID: 36436565 Free PMC article.
The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages.
Domokos A, Varga Z, Jambrovics K, Caballero-Sánchez N, Szabo E, Nagy G, Scholtz B, Halasz L, Varadi E, Bene KP, Mazlo A, Bacsi A, Jeney V, Szebeni GJ, Nagy L, Czimmerer Z. Domokos A, et al. Among authors: halasz l. Front Immunol. 2023 May 4;14:1168635. doi: 10.3389/fimmu.2023.1168635. eCollection 2023. Front Immunol. 2023. PMID: 37215144 Free PMC article.
123 results