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Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Knott GJ, et al. Among authors: fellmann c. Elife. 2019 Aug 9;8:e49110. doi: 10.7554/eLife.49110. Elife. 2019. PMID: 31397669 Free PMC article.
Cornerstones of CRISPR-Cas in drug discovery and therapy.
Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Fellmann C, et al. Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Nat Rev Drug Discov. 2017. PMID: 28008168 Free PMC article. Review.
Systematic discovery of natural CRISPR-Cas12a inhibitors.
Watters KE, Fellmann C, Bai HB, Ren SM, Doudna JA. Watters KE, et al. Among authors: fellmann c. Science. 2018 Oct 12;362(6411):236-239. doi: 10.1126/science.aau5138. Epub 2018 Sep 6. Science. 2018. PMID: 30190307 Free PMC article.
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF. Mancini A, et al. Among authors: fellmann c. Cancer Cell. 2018 Sep 10;34(3):513-528.e8. doi: 10.1016/j.ccell.2018.08.003. Cancer Cell. 2018. PMID: 30205050 Free PMC article.
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Kundert K, et al. Among authors: fellmann c. Nat Commun. 2019 May 9;10(1):2127. doi: 10.1038/s41467-019-09985-2. Nat Commun. 2019. PMID: 31073154 Free PMC article.
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes.
Watters KE, Shivram H, Fellmann C, Lew RJ, McMahon B, Doudna JA. Watters KE, et al. Among authors: fellmann c. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6531-6539. doi: 10.1073/pnas.1917668117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156733 Free PMC article.
Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation.
Lobba MJ, Fellmann C, Marmelstein AM, Maza JC, Kissman EN, Robinson SA, Staahl BT, Urnes C, Lew RJ, Mogilevsky CS, Doudna JA, Francis MB. Lobba MJ, et al. Among authors: fellmann c. ACS Cent Sci. 2020 Sep 23;6(9):1564-1571. doi: 10.1021/acscentsci.0c00940. Epub 2020 Aug 21. ACS Cent Sci. 2020. PMID: 32999931 Free PMC article.
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. Amen AM, et al. Among authors: fellmann c. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2008772118. doi: 10.1073/pnas.2008772118. Proc Natl Acad Sci U S A. 2021. PMID: 33758097 Free PMC article.
41 results